Optical coherent tomography measurements of the diffusion rate of water and drugs in an isolated and whole cornea

K. V. Larin; M. G. Ghosn

doi:10.1070/QE2006v036n12ABEH013225

Optical coherent tomography measurements of the diffusion rate of water and drugs in an isolated and whole cornea

K. V. Larin, M. G. Ghosn

Academic Institute

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The passive diffusion of drugs through the epithelial surfaces of an eye (the most widespread method for medical treatment of various diseases) is considered. The permeability of water and drugs through rabbit cornea was measured in the isolated cornea (separate from an eye) and in the whole cornea. The permeability coefficients of water and dexamethasone were estimated by the method of optical coherence tomography (OCT). Because multiple photon scattering introduces noise and distortions to the OCT signal, measurements were performed at depths up to 500 urn where most likely single scattering of light occurs in cornea. It is shown that the permeability coefficients in the isolated and whole cornea strongly differ from each other. For example, the water permeability in the isolated and whole cornea is (7.09 ± 0.12) × 10^-5 and (1.71 ± 0.51) × 10^-5 cm s^-1, respectively.

Original language	English (US)
Pages (from-to)	1083-1088
Number of pages	6
Journal	Quantum Electronics
Volume	36
Issue number	12
DOIs	https://doi.org/10.1070/QE2006v036n12ABEH013225
State	Published - Dec 2006

Keywords

Cornea
Diffusion
Optical coherence tomography
Single and multiple scattering

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Statistical and Nonlinear Physics
Atomic and Molecular Physics, and Optics
Electrical and Electronic Engineering

Access to Document

10.1070/QE2006v036n12ABEH013225

Cite this

@article{e0b12d852e014d768109cc1204e828d5,

title = "Optical coherent tomography measurements of the diffusion rate of water and drugs in an isolated and whole cornea",

abstract = "The passive diffusion of drugs through the epithelial surfaces of an eye (the most widespread method for medical treatment of various diseases) is considered. The permeability of water and drugs through rabbit cornea was measured in the isolated cornea (separate from an eye) and in the whole cornea. The permeability coefficients of water and dexamethasone were estimated by the method of optical coherence tomography (OCT). Because multiple photon scattering introduces noise and distortions to the OCT signal, measurements were performed at depths up to 500 urn where most likely single scattering of light occurs in cornea. It is shown that the permeability coefficients in the isolated and whole cornea strongly differ from each other. For example, the water permeability in the isolated and whole cornea is (7.09 ± 0.12) × 10-5 and (1.71 ± 0.51) × 10-5 cm s-1, respectively.",

keywords = "Cornea, Diffusion, Optical coherence tomography, Single and multiple scattering",

author = "Larin, {K. V.} and Ghosn, {M. G.}",

year = "2006",

month = dec,

doi = "10.1070/QE2006v036n12ABEH013225",

language = "English (US)",

volume = "36",

pages = "1083--1088",

journal = "Quantum Electronics",

issn = "1063-7818",

publisher = "Turpion Ltd.",

number = "12",

}

TY - JOUR

T1 - Optical coherent tomography measurements of the diffusion rate of water and drugs in an isolated and whole cornea

AU - Larin, K. V.

AU - Ghosn, M. G.

PY - 2006/12

Y1 - 2006/12

N2 - The passive diffusion of drugs through the epithelial surfaces of an eye (the most widespread method for medical treatment of various diseases) is considered. The permeability of water and drugs through rabbit cornea was measured in the isolated cornea (separate from an eye) and in the whole cornea. The permeability coefficients of water and dexamethasone were estimated by the method of optical coherence tomography (OCT). Because multiple photon scattering introduces noise and distortions to the OCT signal, measurements were performed at depths up to 500 urn where most likely single scattering of light occurs in cornea. It is shown that the permeability coefficients in the isolated and whole cornea strongly differ from each other. For example, the water permeability in the isolated and whole cornea is (7.09 ± 0.12) × 10-5 and (1.71 ± 0.51) × 10-5 cm s-1, respectively.

AB - The passive diffusion of drugs through the epithelial surfaces of an eye (the most widespread method for medical treatment of various diseases) is considered. The permeability of water and drugs through rabbit cornea was measured in the isolated cornea (separate from an eye) and in the whole cornea. The permeability coefficients of water and dexamethasone were estimated by the method of optical coherence tomography (OCT). Because multiple photon scattering introduces noise and distortions to the OCT signal, measurements were performed at depths up to 500 urn where most likely single scattering of light occurs in cornea. It is shown that the permeability coefficients in the isolated and whole cornea strongly differ from each other. For example, the water permeability in the isolated and whole cornea is (7.09 ± 0.12) × 10-5 and (1.71 ± 0.51) × 10-5 cm s-1, respectively.

KW - Cornea

KW - Diffusion

KW - Optical coherence tomography

KW - Single and multiple scattering

UR - http://www.scopus.com/inward/record.url?scp=34047266431&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34047266431&partnerID=8YFLogxK

U2 - 10.1070/QE2006v036n12ABEH013225

DO - 10.1070/QE2006v036n12ABEH013225

M3 - Article

AN - SCOPUS:34047266431

VL - 36

SP - 1083

EP - 1088

JO - Quantum Electronics

JF - Quantum Electronics

SN - 1063-7818

IS - 12

ER -

Optical coherent tomography measurements of the diffusion rate of water and drugs in an isolated and whole cornea

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this