@inproceedings{8efdf7307d06434488e7f701b39346c2,
title = "Optical coherence angiography reveals changes in murine fetal brain vasculature due to maternal exposure to nicotine",
abstract = "In the United States, 20% of pregnant women are estimated to smoke, thus affecting 800,000 babies annually. Maternal nicotine exposure is known to have several detrimental effects on the developing fetus including intrauterine growth restriction, perinatal mortality and morbidity, placental abruption, and other childhood disorders. In humans, studies evaluating the association between maternal cigarette smoking during pregnancy and behavioral development in offsprings have shown negative influences of nicotine on brain development. Although several studies have documented lower birth weights, morphological and behavioral changes, not much has been done evaluating the acute changes in brain vasculature after prenatal exposure to nicotine. This work uses correlation mapping optical coherence angiography (cm-OCA), a functional extension of optical coherence tomography, to evaluate changes in murine fetal brain vasculature, in utero, minutes after maternal nicotine exposure. A rapid and significant decrease in vasculature was observed compared to the sham group.",
keywords = "Brain vasculature, Murine embryos, Nicotine, Optical coherence tomography",
author = "Raksha Raghunathan and Liu, {Chih Hao} and Amur Kouka and Yogeshwari Ambekar and Connie Yan and Noemi Bustamante and Manmohan Singh and Miranda, {Rajesh C.} and Larin, {Kirill V.}",
note = "Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; Dynamics and Fluctuations in Biomedical Photonics XVII 2020 ; Conference date: 01-02-2020 Through 03-02-2020",
year = "2020",
doi = "10.1117/12.2554020",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Tuchin, {Valery V.} and Tuchin, {Valery V.} and Leahy, {Martin J.} and Wang, {Ruikang K.}",
booktitle = "Dynamics and Fluctuations in Biomedical Photonics XVII",
address = "United States",
}