Optical clearing for OCT image enhancement and in-depth monitoring of molecular diffusion

Kirill V. Larin; Mohamad G. Ghosn; Alexey N. Bashkatov; Elina A. Genina; Natalia A. Trunina; Valery V. Tuchin

doi:10.1109/JSTQE.2011.2181991

Optical clearing for OCT image enhancement and in-depth monitoring of molecular diffusion

Kirill V. Larin, Mohamad G. Ghosn, Alexey N. Bashkatov, Elina A. Genina, Natalia A. Trunina, Valery V. Tuchin

Academic Institute

Research output: Contribution to journal › Review article › peer-review

100 Scopus citations

Abstract

In this paper, we overview the basic principles, recent results, advantages, limitations, and future of the optical clearing method in application to many fields of biology and medicine. We also discuss the possibility of noninvasive assessment of molecular diffusion in tissues using the optical coherence tomography technique. Issues of safety and toxicity of application of different endogenous and exogenous molecules to tissues are outlined.

Original language	English (US)
Article number	6112786
Pages (from-to)	1244-1259
Number of pages	16
Journal	IEEE Journal on Selected Topics in Quantum Electronics
Volume	18
Issue number	3
DOIs	https://doi.org/10.1109/JSTQE.2011.2181991
State	Published - 2012

Keywords

Molecular diffusion
optical clearing
optical coherence tomography

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Electrical and Electronic Engineering

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10.1109/JSTQE.2011.2181991

Cite this

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title = "Optical clearing for OCT image enhancement and in-depth monitoring of molecular diffusion",

abstract = "In this paper, we overview the basic principles, recent results, advantages, limitations, and future of the optical clearing method in application to many fields of biology and medicine. We also discuss the possibility of noninvasive assessment of molecular diffusion in tissues using the optical coherence tomography technique. Issues of safety and toxicity of application of different endogenous and exogenous molecules to tissues are outlined.",

keywords = "Molecular diffusion, optical clearing, optical coherence tomography",

author = "Larin, \{Kirill V.\} and Ghosn, \{Mohamad G.\} and Bashkatov, \{Alexey N.\} and Genina, \{Elina A.\} and Trunina, \{Natalia A.\} and Tuchin, \{Valery V.\}",

note = "Funding Information: Manuscript received October 26, 2011; revised December 15, 2011; accepted December 15, 2011. Date of publication December 27, 2011; date of current version June 1, 2012. This work was supported in part by the Institute of Biomedical Imaging Sciences under Grant IBIS-97708, the NIH/NHLBI under Grant T32-HL07812, the AHA under Grant 11POST7430064, the Civilian Research and Development Foundation under Grant RUB1-2932-SR-08, and the National Science Foundation under Grant CMMI-0900743; in part by the Russian Foundation for Basic Research under Grant 10-07-00526-a; in part by the Grant 224014 PHOTONICS4LIFE of FP7-ICT-2007-2; in part by the Projects 1.4.09, 2.1.1/4989, and 2.2.1.1/2950 of the RF Ministry of Education and Science; in part by the RF Governmental Contracts 02.740.11.0484, 02.740.11.0770, and 02.740.11.0879; and in part by the FiDiPro, TEKES Program (40111/11), Finland.",

year = "2012",

doi = "10.1109/JSTQE.2011.2181991",

language = "English (US)",

volume = "18",

pages = "1244--1259",

journal = "IEEE Journal on Selected Topics in Quantum Electronics",

issn = "1077-260X",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

number = "3",

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AU - Larin, Kirill V.

AU - Ghosn, Mohamad G.

AU - Bashkatov, Alexey N.

AU - Genina, Elina A.

AU - Trunina, Natalia A.

AU - Tuchin, Valery V.

N1 - Funding Information: Manuscript received October 26, 2011; revised December 15, 2011; accepted December 15, 2011. Date of publication December 27, 2011; date of current version June 1, 2012. This work was supported in part by the Institute of Biomedical Imaging Sciences under Grant IBIS-97708, the NIH/NHLBI under Grant T32-HL07812, the AHA under Grant 11POST7430064, the Civilian Research and Development Foundation under Grant RUB1-2932-SR-08, and the National Science Foundation under Grant CMMI-0900743; in part by the Russian Foundation for Basic Research under Grant 10-07-00526-a; in part by the Grant 224014 PHOTONICS4LIFE of FP7-ICT-2007-2; in part by the Projects 1.4.09, 2.1.1/4989, and 2.2.1.1/2950 of the RF Ministry of Education and Science; in part by the RF Governmental Contracts 02.740.11.0484, 02.740.11.0770, and 02.740.11.0879; and in part by the FiDiPro, TEKES Program (40111/11), Finland.

PY - 2012

Y1 - 2012

N2 - In this paper, we overview the basic principles, recent results, advantages, limitations, and future of the optical clearing method in application to many fields of biology and medicine. We also discuss the possibility of noninvasive assessment of molecular diffusion in tissues using the optical coherence tomography technique. Issues of safety and toxicity of application of different endogenous and exogenous molecules to tissues are outlined.

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KW - optical clearing

KW - optical coherence tomography

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Optical clearing for OCT image enhancement and in-depth monitoring of molecular diffusion

Abstract

Keywords

ASJC Scopus subject areas

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