Optical clearing for OCT image enhancement and in-depth monitoring of molecular diffusion

Kirill V. Larin, Mohamad G. Ghosn, Alexey N. Bashkatov, Elina A. Genina, Natalia A. Trunina, Valery V. Tuchin

Research output: Contribution to journalReview articlepeer-review

78 Scopus citations

Abstract

In this paper, we overview the basic principles, recent results, advantages, limitations, and future of the optical clearing method in application to many fields of biology and medicine. We also discuss the possibility of noninvasive assessment of molecular diffusion in tissues using the optical coherence tomography technique. Issues of safety and toxicity of application of different endogenous and exogenous molecules to tissues are outlined.

Original languageEnglish (US)
Article number6112786
Pages (from-to)1244-1259
Number of pages16
JournalIEEE Journal on Selected Topics in Quantum Electronics
Volume18
Issue number3
DOIs
StatePublished - 2012

Keywords

  • Molecular diffusion
  • optical clearing
  • optical coherence tomography

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering

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