TY - JOUR
T1 - Ophthalmic and Systemic Factors of Acute Nonarteritic Anterior Ischemic Optic Neuropathy in the Quark207 Treatment Trial
AU - Quark207 NAION Study Group
AU - Kupersmith, Mark J.
AU - Fraser, Clare L.
AU - Morgenstern, Rachelle
AU - Miller, Neil R.
AU - Levin, Leonard A.
AU - Jette, Nathalie
AU - Clare, Fraser
AU - Celia, Chen
AU - Neil, Shuey
AU - Stephen, Colley
AU - Wang, Ningli
AU - Dou, Hongliang
AU - Zhong, Yong
AU - Tang, Luosheng
AU - Han, Quanhong
AU - Dirk, Sandner
AU - Maria-Andreea, Gamulescu
AU - Nicole, Eter
AU - Helmut, Wilhelm
AU - Katrin, Lorenz
AU - Santhosh, Krishna G.
AU - Ramesh, Kekunnaya
AU - S, Ambika
AU - Kumudini, Sharma
AU - Warkad, Vivekanand Uttamrao
AU - Rohit, Saxena
AU - Mahesh, Kumar S.
AU - Dipankar, Das
AU - Atul, Hegade
AU - Shahana, Mazumdar
AU - Sachin, Daighavane
AU - Virender, Sachdeva
AU - Hadas, Kalish
AU - Ainat, Klein
AU - Ruth, Huna Baron
AU - Hana, Leiba
AU - Nitza, Goldenberg Cohen
AU - Marina, Shneck
AU - Joshua, Kruger
AU - Pasquale, Ciardella Antonio
AU - Gianni, Virgili
AU - Arturo, Carta
AU - Stefania, Bianchi Marzoli
AU - Tow, Sharon
AU - Fang, Chin Chee
AU - Peter, MacIntosh
AU - Jeffrey, Bennett
AU - Byron, Lam
AU - Rosa, Tang
AU - Andrew, Lee
N1 - Publisher Copyright:
© 2024 American Academy of Ophthalmology
PY - 2024/7
Y1 - 2024/7
N2 - Purpose: We describe the baseline ophthalmic and cardiovascular risk factors across countries, race, and sex for the Quark207 treatment trial for acute nonarteritic anterior ischemic optic neuropathy (NAION). Design: Prospective, randomized controlled clinical trial. Participants: Adults 50 to 80 years of age with acute NAION recruited from 80 sites across 8 countries. Main Outcome Measures: Ophthalmic features of NAION and cardiovascular risk factors. Methods: We evaluated demographics and clinical and ophthalmologic data, including best-corrected visual acuity (BCVA) and average visual field total deviation (TD), in affected eyes and cup-to-disc ratio in fellow eyes at enrollment. We report the prevalence (mean and standard devition, and median and interquartile range [IQR]) of ophthalmic features and cardiovascular risk factors, stratified by country, race, and sex. We corrected for multiple comparisons using Dunn's test with Bonferroni correction for continuous variables and chi-square testing with Holm-Bonferroni correction for categorical variables. Results: The study enrolled 500 men and 229 women with a median age of 60 and 61 years (P = 0.027), respectively. Participants were predominantly White (n = 570) and Asian (n = 149). The study eye BCVA was 71 characters (IQR, 53–84 characters; approximately 0.4 logarithm of the minimum angle of resolution), and the TD was –16.5 dB (IQR, –22.2 to –12.6 dB) for stimulus III and –15.7 dB (IQR, –20.8 to –10.9 dB) for stimulus V. The vertical and horizontal cup-to-disc ratio was 0.1 (IQR, 0.1–0.3) for unaffected fellow eyes. The prevalence of cardiovascular risk factors varied among countries. The most notable differences were in the baseline comorbidities and ophthalmologic features, which differed between Asian and White races. Men and women differed with respect to a few clinically meaningful features. Conclusions: The cardiovascular risk factors in the NAION cohort varied among the 7 countries, race, and sex, but were not typically more prevalent than in the general population. Ophthalmic features, typical of NAION, generally were consistent across countries, race, and sex, except for worse BCVA and TD in China. Men have a frequency of NAION twice that of women. Having a small cup-to-disc ratio in the fellow eye was the most prevalent risk factor across all demographics. This study suggests that factors, not yet identified, may contribute to the development of NAION. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
AB - Purpose: We describe the baseline ophthalmic and cardiovascular risk factors across countries, race, and sex for the Quark207 treatment trial for acute nonarteritic anterior ischemic optic neuropathy (NAION). Design: Prospective, randomized controlled clinical trial. Participants: Adults 50 to 80 years of age with acute NAION recruited from 80 sites across 8 countries. Main Outcome Measures: Ophthalmic features of NAION and cardiovascular risk factors. Methods: We evaluated demographics and clinical and ophthalmologic data, including best-corrected visual acuity (BCVA) and average visual field total deviation (TD), in affected eyes and cup-to-disc ratio in fellow eyes at enrollment. We report the prevalence (mean and standard devition, and median and interquartile range [IQR]) of ophthalmic features and cardiovascular risk factors, stratified by country, race, and sex. We corrected for multiple comparisons using Dunn's test with Bonferroni correction for continuous variables and chi-square testing with Holm-Bonferroni correction for categorical variables. Results: The study enrolled 500 men and 229 women with a median age of 60 and 61 years (P = 0.027), respectively. Participants were predominantly White (n = 570) and Asian (n = 149). The study eye BCVA was 71 characters (IQR, 53–84 characters; approximately 0.4 logarithm of the minimum angle of resolution), and the TD was –16.5 dB (IQR, –22.2 to –12.6 dB) for stimulus III and –15.7 dB (IQR, –20.8 to –10.9 dB) for stimulus V. The vertical and horizontal cup-to-disc ratio was 0.1 (IQR, 0.1–0.3) for unaffected fellow eyes. The prevalence of cardiovascular risk factors varied among countries. The most notable differences were in the baseline comorbidities and ophthalmologic features, which differed between Asian and White races. Men and women differed with respect to a few clinically meaningful features. Conclusions: The cardiovascular risk factors in the NAION cohort varied among the 7 countries, race, and sex, but were not typically more prevalent than in the general population. Ophthalmic features, typical of NAION, generally were consistent across countries, race, and sex, except for worse BCVA and TD in China. Men have a frequency of NAION twice that of women. Having a small cup-to-disc ratio in the fellow eye was the most prevalent risk factor across all demographics. This study suggests that factors, not yet identified, may contribute to the development of NAION. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
KW - Cardiovascular risk factors
KW - Nonarteritic anterior ischemic optic neuropathy
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U2 - 10.1016/j.ophtha.2024.01.011
DO - 10.1016/j.ophtha.2024.01.011
M3 - Article
C2 - 38211825
AN - SCOPUS:85185570326
SN - 0161-6420
VL - 131
SP - 790
EP - 802
JO - Ophthalmology
JF - Ophthalmology
IS - 7
ER -