Ontogeny of dopamine transporter mRNA expression in the rat brain

Masahiro Fujita, Shoichi Shimada, Tsunehiko Nishimura, George R. Uhl, Masaya Tohyama

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


The ontogeny of dopamine transporter (DAT) gene expression was studied in the rat brain. DAT mRNA was first detected in neurons of the ventrocaudal mesencephalon on embryonic day 14 (E14). By E18, intensely expressing neurons in the ventral tegmental area and substantia nigra resembled the pattern found in adult midbrain. DAT mRNA is not abundant in the hypothalamus and the olfactory bulb at any stage of development. These results parallel those noted for tyrosine hydroxylase gene expression in mesencephalon.

Original languageEnglish (US)
Pages (from-to)222-226
Number of pages5
JournalMolecular Brain Research
Issue number3
StatePublished - Aug 1993


  • Dopamine transporter
  • In situ hybridization histochemistry
  • Ontogeny
  • Substantia nigra
  • Ventral tegmental area

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience


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