Oncogene activation in esophageal cancer

A. G. Casson; T. Mukhopadhyay; K. R. Cleary; J. Y. Ro; B. Levin; J. A. Roth

doi:10.1016/s0022-5223(19)36860-6

Oncogene activation in esophageal cancer

A. G. Casson, T. Mukhopadhyay, K. R. Cleary, J. Y. Ro, B. Levin, J. A. Roth

Academic Institute

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

We used molecular biology techniques to study the genetic events associated with the development of human esophageal cancer. Point mutations of the p53 tumor suppressor gene were detected in one of 10 squamous cell and one of 14 adenocarcinomas of the esophagus, a frequency that implicates this gene in tumorigenesis. However, the finding of p53 mutations in Barrett's epithelium adjacent to adenocarcinomas may have clinical implications for p53 as a premalignant marker for esophageal cancer.

Original language	English (US)
Pages (from-to)	707-709
Number of pages	3
Journal	Journal of Thoracic and Cardiovascular Surgery
Volume	102
Issue number	5
DOIs	https://doi.org/10.1016/s0022-5223(19)36860-6
State	Published - 1991

ASJC Scopus subject areas

Surgery
Pulmonary and Respiratory Medicine
Cardiology and Cardiovascular Medicine

Access to Document

10.1016/s0022-5223(19)36860-6

Cite this

@article{d39aa861e5be41c9a121ac1cff4fda92,

title = "Oncogene activation in esophageal cancer",

abstract = "We used molecular biology techniques to study the genetic events associated with the development of human esophageal cancer. Point mutations of the p53 tumor suppressor gene were detected in one of 10 squamous cell and one of 14 adenocarcinomas of the esophagus, a frequency that implicates this gene in tumorigenesis. However, the finding of p53 mutations in Barrett's epithelium adjacent to adenocarcinomas may have clinical implications for p53 as a premalignant marker for esophageal cancer.",

author = "Casson, {A. G.} and T. Mukhopadhyay and Cleary, {K. R.} and Ro, {J. Y.} and B. Levin and Roth, {J. A.}",

year = "1991",

doi = "10.1016/s0022-5223(19)36860-6",

language = "English (US)",

volume = "102",

pages = "707--709",

journal = "Journal of Thoracic and Cardiovascular Surgery",

issn = "0022-5223",

publisher = "Mosby Inc.",

number = "5",

}

TY - JOUR

T1 - Oncogene activation in esophageal cancer

AU - Casson, A. G.

AU - Mukhopadhyay, T.

AU - Cleary, K. R.

AU - Ro, J. Y.

AU - Levin, B.

AU - Roth, J. A.

PY - 1991

Y1 - 1991

N2 - We used molecular biology techniques to study the genetic events associated with the development of human esophageal cancer. Point mutations of the p53 tumor suppressor gene were detected in one of 10 squamous cell and one of 14 adenocarcinomas of the esophagus, a frequency that implicates this gene in tumorigenesis. However, the finding of p53 mutations in Barrett's epithelium adjacent to adenocarcinomas may have clinical implications for p53 as a premalignant marker for esophageal cancer.

AB - We used molecular biology techniques to study the genetic events associated with the development of human esophageal cancer. Point mutations of the p53 tumor suppressor gene were detected in one of 10 squamous cell and one of 14 adenocarcinomas of the esophagus, a frequency that implicates this gene in tumorigenesis. However, the finding of p53 mutations in Barrett's epithelium adjacent to adenocarcinomas may have clinical implications for p53 as a premalignant marker for esophageal cancer.

UR - http://www.scopus.com/inward/record.url?scp=0026338971&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026338971&partnerID=8YFLogxK

U2 - 10.1016/s0022-5223(19)36860-6

DO - 10.1016/s0022-5223(19)36860-6

M3 - Article

C2 - 1943188

AN - SCOPUS:0026338971

SN - 0022-5223

VL - 102

SP - 707

EP - 709

JO - Journal of Thoracic and Cardiovascular Surgery

JF - Journal of Thoracic and Cardiovascular Surgery

IS - 5

ER -

Oncogene activation in esophageal cancer

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this