A 60-year-old man presented with diplopia and neurocognitive deficits, which progressed rapidly over several months. Magnetic resonance imaging of the head revealed bilateral signal abnormalities and diffusion-weighted imaging restriction in bilateral basal ganglia, thalami, mesial temporal regions, and periaqueductal gray matter. Cerebrospinal fluid analysis was positive for 14-3-3 and tau proteins. The patient developed progressive neurocognitive decline followed by sleep disturbance and myoclonic jerking consistent with probable Creutzfeldt-Jakob disease.

Original languageEnglish (US)
Pages (from-to)379-385
Number of pages7
JournalSurvey of Ophthalmology
Issue number4
StatePublished - Jul 2012


  • 14-3-3
  • Creutzfeldt-Jakob disease
  • Diffusion-weighted imaging
  • Diplopia
  • Neurocognitive

ASJC Scopus subject areas

  • Ophthalmology


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