On the Possibility of Estimating Myocardial Fiber Architecture from Cardiac Strains

Muhammad Usman, Emilio A. Mendiola, Tanmay Mukherjee, Rana Raza Mehdi, Jacques Ohayon, Prasanna G. Alluri, Sakthivel Sadayappan, Gaurav Choudhary, Reza Avazmohammadi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

The myocardium is composed of a complex network of contractile myofibers that are organized in such a way as to produce efficient contraction and relaxation of the heart. The myofiber architecture in the myocardium is a key determinant of cardiac motion and the global or organ-level function of the heart. Reports of architectural remodeling in cardiac diseases, such as pulmonary hypertension and myocardial infarction, potentially contributing to cardiac dysfunction call for the inclusion of an architectural marker for an improved assessment of cardiac function. However, the in-vivo quantification of three-dimensional myo-architecture has proven challenging. In this work, we examine the sensitivity of cardiac strains to varying myofiber orientation using a multiscale finite-element model of the LV. Additionally, we present an inverse modeling approach to predict the myocardium fiber structure from cardiac strains. Our results indicate a strong correlation between fiber orientation and LV kinematics, corroborating that the fiber structure is a principal determinant of LV contractile behavior. Our inverse model was capable of accurately predicting the myocardial fiber range and regional fiber angles from strain measures. A concrete understanding of the link between LV myofiber structure and motion, and the development of non-invasive and feasible means of characterizing the myocardium architecture is expected to lead to advanced LV functional metrics and improved prognostic assessment of structural heart disease.

Original languageEnglish (US)
Title of host publicationFunctional Imaging and Modeling of the Heart - 12th International Conference, FIMH 2023, Proceedings
EditorsOlivier Bernard, Patrick Clarysse, Nicolas Duchateau, Jacques Ohayon, Magalie Viallon
PublisherSpringer Science and Business Media Deutschland GmbH
Pages74-83
Number of pages10
Volume13958
ISBN (Print)9783031353017
DOIs
StatePublished - Jun 2023
EventFunctional Imaging and Modeling of the Heart - 12th International Conference, FIMH 2023, Proceedings - Lyon, France
Duration: Jun 19 2023Jun 22 2023

Publication series

NameFunctional imaging and modeling of the heart : ... International Workshop, FIMH ..., proceedings. FIMH

Conference

ConferenceFunctional Imaging and Modeling of the Heart - 12th International Conference, FIMH 2023, Proceedings
Country/TerritoryFrance
CityLyon
Period6/19/236/22/23

Keywords

  • Myocardium architecture
  • cardiac strains
  • left ventricle
  • magnetic resonance imaging

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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