TY - JOUR
T1 - On the intersection of molecular bioelectronics and biosensors
T2 - 20 Years of C3B
AU - Aggas, John R.
AU - Walther, Brandon K.
AU - Abasi, Sara
AU - Kotanen, Christian N.
AU - Karunwi, Olukayode
AU - Wilson, Ann M.
AU - Guiseppi-Elie, Anthony
N1 - Funding Information:
Prof. Dr. A. G.-E. is founder and scientific director of ABTECH Scientific, Inc., manufacturer of microfabricated biochip devices. He is a Fulbright Specialist sponsored by the US Department of State through World Learning and has been appointed to University of Tucumán, Argentina (UT - 2015) and Wroclaw University of Science and Technology, Poland (WUST – 2019). He has been funded by the Burroughs Wellcome Fund (2019). Support was received from the Consortium of the Center for Bioelectronics, Biosensors, and Biochips (C3B®) and ABTECH Scientific, Inc. The authors acknowledge the support of Texas Engineering Experiment Station (TEES) via a TEES Research Professorship.
Funding Information:
Prof. Dr. A. G.-E. is founder and scientific director of ABTECH Scientific, Inc., manufacturer of microfabricated biochip devices. He is a Fulbright Specialist sponsored by the US Department of State through World Learning and has been appointed to University of Tucum?n, Argentina (UT - 2015) and Wroclaw University of Science and Technology, Poland (WUST ? 2019). He has been funded by the Burroughs Wellcome Fund (2019). Support was received from the Consortium of the Center for Bioelectronics, Biosensors, and Biochips (C3B?) and ABTECH Scientific, Inc. The authors acknowledge the support of Texas Engineering Experiment Station (TEES) via a TEES Research Professorship.
Funding Information:
The authors acknowledge the support of Texas Engineering Experiment Station (TEES) through a professorship to AG-E; ABTECH Scientific, Inc. for providing access to biochip substrates and the support of the consortium of the C3B. The authors thank Dale Conrad and Chris Akers for their artistic talents in creating figure schematics.
Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2021/3/15
Y1 - 2021/3/15
N2 - Formed in 2000 at Virginia Commonwealth University, the Center for Bioelectronics, Biosensors and Biochips (C3B®) has subsequently been located at Clemson University and at Texas A&M University. Established as an industry-university collaborative center of excellence, the C3B has contributed new knowledge and technology in the areas of i) molecular bioelectronics, ii) responsive polymers, iii) multiplexed biosensor systems, and iv) bioelectronic biosensors. Noteworthy contributions in these areas include i) being the first to report direct electron transfer of oxidoreductase enzymes enabled by single walled carbon nanotubes and colloidal clays, ii) the molecular level integration of inherently conductive polymers with bioactive hydrogels using bi-functional monomers such as poly(pyrrole-co-3-pyrrolylbutyrate-conj-aminoethylmethacrylate) [PyBA-conj-AEMA] and 3-(1-ethyl methacryloylate)aniline to yield hetero-ladder electroconductive hydrogels, iii) the development of a multi-analyte physiological status monitoring biochip, and iv) the development of a bioanalytical Wien-bridge oscillator for the fused measurement to lactate and glucose. The present review takes a critical look of these contributions over the past 20 years and offers some perspective on the future of bioelectronics-based biosensors and systems. Particular attention is given to multiplexed biosensor systems and data fusion for rapid decision making.
AB - Formed in 2000 at Virginia Commonwealth University, the Center for Bioelectronics, Biosensors and Biochips (C3B®) has subsequently been located at Clemson University and at Texas A&M University. Established as an industry-university collaborative center of excellence, the C3B has contributed new knowledge and technology in the areas of i) molecular bioelectronics, ii) responsive polymers, iii) multiplexed biosensor systems, and iv) bioelectronic biosensors. Noteworthy contributions in these areas include i) being the first to report direct electron transfer of oxidoreductase enzymes enabled by single walled carbon nanotubes and colloidal clays, ii) the molecular level integration of inherently conductive polymers with bioactive hydrogels using bi-functional monomers such as poly(pyrrole-co-3-pyrrolylbutyrate-conj-aminoethylmethacrylate) [PyBA-conj-AEMA] and 3-(1-ethyl methacryloylate)aniline to yield hetero-ladder electroconductive hydrogels, iii) the development of a multi-analyte physiological status monitoring biochip, and iv) the development of a bioanalytical Wien-bridge oscillator for the fused measurement to lactate and glucose. The present review takes a critical look of these contributions over the past 20 years and offers some perspective on the future of bioelectronics-based biosensors and systems. Particular attention is given to multiplexed biosensor systems and data fusion for rapid decision making.
KW - Biodevices
KW - Bioelectronics
KW - Data fusion
KW - Multiplexed biosensors
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U2 - 10.1016/j.bios.2020.112889
DO - 10.1016/j.bios.2020.112889
M3 - Article
C2 - 33358581
AN - SCOPUS:85098216124
SN - 0956-5663
VL - 176
JO - Biosensors and Bioelectronics
JF - Biosensors and Bioelectronics
M1 - 112889
ER -