On the Hepatic Sulphurylating Activity in Male Pseudohermaphroditic Rats

Jan Åke Gustafsson, Jan Carlstedt-Duke, Allen S. Goldman

    Research output: Contribution to journalArticlepeer-review

    4 Scopus citations

    Abstract

    The sulphurylation of [1,2-3H]-deoxycorticosterone was studied in the 105,000g supernatant fluid obtained from liver homogenates of intact and castrated male pseudohermaphroditic, normal female, and normal male rats with and without treatment with steroid hormones. Male pseudohermaphroditic and normal female rats had similar sulphurylating activities which were higher than that of normal male rats. It was shown that the sulphurylating activity in male pseudohermaphroditic and normal female rats is normally regulated mainly by nongonadal factors and that the sulphurylating activity in normal male rats is suppressed by testicular androgens.

    Original languageEnglish (US)
    Pages (from-to)908-911
    Number of pages4
    JournalProceedings of the Society for Experimental Biology and Medicine
    Volume145
    Issue number3
    DOIs
    StatePublished - Mar 1974

    ASJC Scopus subject areas

    • General Biochemistry, Genetics and Molecular Biology

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