On the Hepatic Sulphurylating Activity in Male Pseudohermaphroditic Rats

Jan Åke Gustafsson; Jan Carlstedt-Duke; Allen S. Goldman

doi:10.3181/00379727-145-37922

On the Hepatic Sulphurylating Activity in Male Pseudohermaphroditic Rats

Jan Åke Gustafsson, Jan Carlstedt-Duke, Allen S. Goldman

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The sulphurylation of [1,2-³H]-deoxycorticosterone was studied in the 105,000g supernatant fluid obtained from liver homogenates of intact and castrated male pseudohermaphroditic, normal female, and normal male rats with and without treatment with steroid hormones. Male pseudohermaphroditic and normal female rats had similar sulphurylating activities which were higher than that of normal male rats. It was shown that the sulphurylating activity in male pseudohermaphroditic and normal female rats is normally regulated mainly by nongonadal factors and that the sulphurylating activity in normal male rats is suppressed by testicular androgens.

Original language	English (US)
Pages (from-to)	908-911
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	145
Issue number	3
DOIs	https://doi.org/10.3181/00379727-145-37922
State	Published - Mar 1974

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "On the Hepatic Sulphurylating Activity in Male Pseudohermaphroditic Rats",

abstract = "The sulphurylation of [1,2-3H]-deoxycorticosterone was studied in the 105,000g supernatant fluid obtained from liver homogenates of intact and castrated male pseudohermaphroditic, normal female, and normal male rats with and without treatment with steroid hormones. Male pseudohermaphroditic and normal female rats had similar sulphurylating activities which were higher than that of normal male rats. It was shown that the sulphurylating activity in male pseudohermaphroditic and normal female rats is normally regulated mainly by nongonadal factors and that the sulphurylating activity in normal male rats is suppressed by testicular androgens.",

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note = "Funding Information: Aided by research grants from the U.S.P.H.S. (HD-4683), the Rockefeller Foundation, the Swedish Medical Research Council (13X-2819), and Carl-Bertel Nathhorsts Vetenskapliga Stiftelse. 2 ",

year = "1974",

month = mar,

doi = "10.3181/00379727-145-37922",

language = "English (US)",

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journal = "Proceedings of the Society for Experimental Biology and Medicine",

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T1 - On the Hepatic Sulphurylating Activity in Male Pseudohermaphroditic Rats

AU - Gustafsson, Jan Åke

AU - Carlstedt-Duke, Jan

AU - Goldman, Allen S.

N1 - Funding Information: Aided by research grants from the U.S.P.H.S. (HD-4683), the Rockefeller Foundation, the Swedish Medical Research Council (13X-2819), and Carl-Bertel Nathhorsts Vetenskapliga Stiftelse. 2

PY - 1974/3

Y1 - 1974/3

N2 - The sulphurylation of [1,2-3H]-deoxycorticosterone was studied in the 105,000g supernatant fluid obtained from liver homogenates of intact and castrated male pseudohermaphroditic, normal female, and normal male rats with and without treatment with steroid hormones. Male pseudohermaphroditic and normal female rats had similar sulphurylating activities which were higher than that of normal male rats. It was shown that the sulphurylating activity in male pseudohermaphroditic and normal female rats is normally regulated mainly by nongonadal factors and that the sulphurylating activity in normal male rats is suppressed by testicular androgens.

AB - The sulphurylation of [1,2-3H]-deoxycorticosterone was studied in the 105,000g supernatant fluid obtained from liver homogenates of intact and castrated male pseudohermaphroditic, normal female, and normal male rats with and without treatment with steroid hormones. Male pseudohermaphroditic and normal female rats had similar sulphurylating activities which were higher than that of normal male rats. It was shown that the sulphurylating activity in male pseudohermaphroditic and normal female rats is normally regulated mainly by nongonadal factors and that the sulphurylating activity in normal male rats is suppressed by testicular androgens.

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On the Hepatic Sulphurylating Activity in Male Pseudohermaphroditic Rats

Abstract

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