TY - JOUR
T1 - On the generality of the finite element modeling physical fields in biological systems by the multiscale smeared concept (Kojic transport model)
AU - Kojic, Milos
AU - Milosevic, Miljan
AU - Simic, Vladimir
AU - Milicevic, Bogdan
AU - Terracciano, Rossana
AU - Filgueira, Carly S.
N1 - Publisher Copyright:
© 2024
PY - 2024/3/15
Y1 - 2024/3/15
N2 - The biomechanical and biochemical processes in the biological systems of living organisms are extremely complex. Advances in understanding these processes are mainly achieved by laboratory and clinical investigations, but in recent decades they are supported by computational modeling. Besides enormous efforts and achievements in this modeling, there still is a need for new methods that can be used in everyday research and medical practice. In this report, we give a view of the generality of the finite element methodology introduced by the first author and supported by his collaborators. It is based on the multiscale smeared physical fields, termed as Kojic Transport Model (KTM), published in several journal papers and summarized in a recent book (Kojic et al., 2022) [1]. We review relevant literature to demonstrate the distinctions and advantages of our methodology and indicate possible further applications. We refer to our published results by a selection of a few examples which include modeling of partitioning, blood flow, molecular transport within the pancreas, multiscale-multiphysics model of coupling electrical field and ion concentration, and a model of convective-diffusive transport within the lung parenchyma. Two new examples include a model of convective-diffusive transport within a growing tumor, and drug release from nanofibers with fiber degradation.
AB - The biomechanical and biochemical processes in the biological systems of living organisms are extremely complex. Advances in understanding these processes are mainly achieved by laboratory and clinical investigations, but in recent decades they are supported by computational modeling. Besides enormous efforts and achievements in this modeling, there still is a need for new methods that can be used in everyday research and medical practice. In this report, we give a view of the generality of the finite element methodology introduced by the first author and supported by his collaborators. It is based on the multiscale smeared physical fields, termed as Kojic Transport Model (KTM), published in several journal papers and summarized in a recent book (Kojic et al., 2022) [1]. We review relevant literature to demonstrate the distinctions and advantages of our methodology and indicate possible further applications. We refer to our published results by a selection of a few examples which include modeling of partitioning, blood flow, molecular transport within the pancreas, multiscale-multiphysics model of coupling electrical field and ion concentration, and a model of convective-diffusive transport within the lung parenchyma. Two new examples include a model of convective-diffusive transport within a growing tumor, and drug release from nanofibers with fiber degradation.
KW - Composite smeared finite element
KW - Convective-diffusive transport
KW - Kojic transport model
KW - Lung parenchyma
KW - Multiscale-multiphysics models
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U2 - 10.1016/j.heliyon.2024.e26354
DO - 10.1016/j.heliyon.2024.e26354
M3 - Article
C2 - 38434281
SN - 2405-8440
VL - 10
SP - e26354
JO - Heliyon
JF - Heliyon
IS - 5
M1 - e26354
ER -