On the catecholamine control of growth hormone regulation. Evidence for discrete changes in dopamine and noradrenaline turnover following growth hormone administration

K. Andersson, K. Fuxe, P. Eneroth, Jan-Ake Gustafsson, P. Skett

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Two hours following treatment with rat growth hormone (100 μg/kg, i.v.) a reduction of noradrenaline (NA) levels in the rat's hypothalamic subependymal layer was observed. Further findings indicate a reduction of dopamine (DA) turnover in the medial and lateral palisade zone of the median eminence and of NA turnover in the posterior perinventicular hypothalamic region. This suggests thee existence of a facilitory noradrenergic mechanism in the posterior periventricular hypothalamic region facilitating growth hormone secretion and that of an inhibitory dopaminergic mechanism in the medial palisade zone inhibiting the secretion of somatostatin.

Original languageEnglish (US)
Pages (from-to)83-89
Number of pages7
JournalNeuroscience Letters
Volume5
Issue number1-2
DOIs
StatePublished - Jan 1 1977

ASJC Scopus subject areas

  • Neuroscience(all)

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