On-chip coupling of electrochemical pumps and an SU-8 tip for electrospray ionization mass spectrometry

Seung Min Park; Kelvin H. Lee; Harold G. Craighead

doi:10.1007/s10544-008-9203-6

On-chip coupling of electrochemical pumps and an SU-8 tip for electrospray ionization mass spectrometry

Seung Min Park, Kelvin H. Lee, Harold G. Craighead

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We present the integration of a cyclo olefin copolymer microfluidic chip with electrochemical pumps and an SU-8 tip for electrospray ionization mass spectrometry. The electrochemical pump, using electrolysis as an internal pressure source, was fabricated directly on the surface of the polymer chip. The triangular SU-8 emitter tip was fabricated on a glass wafer using standard photolithography. After release from the glass wafer, this tip was aligned to the microchannel and bonded between two polymer plates. The electrochemical pump and the electrospray tip were tested with electrospray ionization mass spectrometry. Mass spectrometry confirmed the stability of the electrochemical pump and the electrospray tip.

Original language	English (US)
Pages (from-to)	891-897
Number of pages	7
Journal	Biomedical Microdevices
Volume	10
Issue number	6
DOIs	https://doi.org/10.1007/s10544-008-9203-6
State	Published - 2008

Keywords

Electrochemical pump
ESI-MS
Polymer microfluidic chip
SU-8tip

ASJC Scopus subject areas

Biomedical Engineering
Molecular Biology

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10.1007/s10544-008-9203-6

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title = "On-chip coupling of electrochemical pumps and an SU-8 tip for electrospray ionization mass spectrometry",

abstract = "We present the integration of a cyclo olefin copolymer microfluidic chip with electrochemical pumps and an SU-8 tip for electrospray ionization mass spectrometry. The electrochemical pump, using electrolysis as an internal pressure source, was fabricated directly on the surface of the polymer chip. The triangular SU-8 emitter tip was fabricated on a glass wafer using standard photolithography. After release from the glass wafer, this tip was aligned to the microchannel and bonded between two polymer plates. The electrochemical pump and the electrospray tip were tested with electrospray ionization mass spectrometry. Mass spectrometry confirmed the stability of the electrochemical pump and the electrospray tip.",

keywords = "Electrochemical pump, ESI-MS, Polymer microfluidic chip, SU-8tip",

author = "Park, {Seung Min} and Lee, {Kelvin H.} and Craighead, {Harold G.}",

note = "Funding Information: Acknowledgements The authors would like to thank Pei-yu Liao and Leila Choe for help with mass spectrometry analysis and Dr. Yanou Yang for help with overall discussion. The work was supported in part by the Nanobiotechnology Center (NBTC), an STC Program of the National Science Foundation under Agreement No. ECS-9876771 and by the Institute for the Study of Aging. The authors would appreciate access and use of the Cornell Nanoscale Science and Technology Facility (a member of the National Nanofabrication Users Network). Copyright: Copyright 2009 Elsevier B.V., All rights reserved.",

year = "2008",

doi = "10.1007/s10544-008-9203-6",

language = "English (US)",

volume = "10",

pages = "891--897",

journal = "Biomedical Microdevices",

issn = "1387-2176",

publisher = "Kluwer Academic Publishers",

number = "6",

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TY - JOUR

T1 - On-chip coupling of electrochemical pumps and an SU-8 tip for electrospray ionization mass spectrometry

AU - Park, Seung Min

AU - Lee, Kelvin H.

AU - Craighead, Harold G.

N1 - Funding Information: Acknowledgements The authors would like to thank Pei-yu Liao and Leila Choe for help with mass spectrometry analysis and Dr. Yanou Yang for help with overall discussion. The work was supported in part by the Nanobiotechnology Center (NBTC), an STC Program of the National Science Foundation under Agreement No. ECS-9876771 and by the Institute for the Study of Aging. The authors would appreciate access and use of the Cornell Nanoscale Science and Technology Facility (a member of the National Nanofabrication Users Network). Copyright: Copyright 2009 Elsevier B.V., All rights reserved.

PY - 2008

Y1 - 2008

N2 - We present the integration of a cyclo olefin copolymer microfluidic chip with electrochemical pumps and an SU-8 tip for electrospray ionization mass spectrometry. The electrochemical pump, using electrolysis as an internal pressure source, was fabricated directly on the surface of the polymer chip. The triangular SU-8 emitter tip was fabricated on a glass wafer using standard photolithography. After release from the glass wafer, this tip was aligned to the microchannel and bonded between two polymer plates. The electrochemical pump and the electrospray tip were tested with electrospray ionization mass spectrometry. Mass spectrometry confirmed the stability of the electrochemical pump and the electrospray tip.

AB - We present the integration of a cyclo olefin copolymer microfluidic chip with electrochemical pumps and an SU-8 tip for electrospray ionization mass spectrometry. The electrochemical pump, using electrolysis as an internal pressure source, was fabricated directly on the surface of the polymer chip. The triangular SU-8 emitter tip was fabricated on a glass wafer using standard photolithography. After release from the glass wafer, this tip was aligned to the microchannel and bonded between two polymer plates. The electrochemical pump and the electrospray tip were tested with electrospray ionization mass spectrometry. Mass spectrometry confirmed the stability of the electrochemical pump and the electrospray tip.

KW - Electrochemical pump

KW - ESI-MS

KW - Polymer microfluidic chip

KW - SU-8tip

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U2 - 10.1007/s10544-008-9203-6

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M3 - Article

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AN - SCOPUS:52449096333

VL - 10

SP - 891

EP - 897

JO - Biomedical Microdevices

JF - Biomedical Microdevices

SN - 1387-2176

IS - 6

ER -

On-chip coupling of electrochemical pumps and an SU-8 tip for electrospray ionization mass spectrometry

Abstract

Keywords

ASJC Scopus subject areas

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