Oligonucleotide-based theranostic nanoparticles in cancer therapy

Reza Shahbazi, Bulent Ozpolat, Kezban Ulubayram

    Research output: Contribution to journalReview articlepeer-review

    37 Scopus citations


    Theranostic approaches, combining the functionality of both therapy and imaging, have shown potential in cancer nanomedicine. Oligonucleotides such as small interfering RNA and microRNA, which are powerful therapeutic agents, have been effectively employed in theranostic systems against various cancers. Nanoparticles are used to deliver oligonucleotides into tumors by passive or active targeting while protecting the oligonucleotides from nucleases in the extracellular environment. The use of quantum dots, iron oxide nanoparticles and gold nanoparticles and tagging with contrast agents, like fluorescent dyes, optical or magnetic agents and various radioisotopes, has facilitated early detection of tumors and evaluation of therapeutic efficacy. In this article, we review the advantages of theranostic applications in cancer therapy and imaging, with special attention to oligonucleotide-based therapeutics.

    Original languageEnglish (US)
    Pages (from-to)1287-1308
    Number of pages22
    Issue number10
    StatePublished - May 2016


    • cancer imaging
    • cancer therapy
    • nanoparticle
    • oligonucleotide
    • theranostics

    ASJC Scopus subject areas

    • Bioengineering
    • Medicine (miscellaneous)
    • Biomedical Engineering
    • Materials Science(all)


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