Oligonucleotide Aptamer-Mediated Precision Therapy of Hematological Malignancies

Shuanghui Yang, Huan Li, Ling Xu, Zhenhan Deng, Wei Han, Yanting Liu, Wenqi Jiang, Youli Zu

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Precision medicine has recently emerged as a promising strategy for cancer therapy because it not only specifically targets cancer cells but it also does not have adverse effects on normal cells. Oligonucleotide aptamers are a class of small molecule ligands that can specifically bind to their targets on cell surfaces with high affinity. Aptamers have great potential in precision cancer therapy due to their unique physical, chemical, and biological properties. Therefore, aptamer technology has been widely investigated for biomedical and clinical applications. This review focuses on the potential applications of aptamer technology as a new tool for precision treatment of hematological malignancies, including leukemia, lymphoma, and multiple myeloma.

Original languageEnglish (US)
Pages (from-to)164-175
Number of pages12
JournalMolecular Therapy - Nucleic Acids
Volume13
DOIs
StatePublished - Dec 7 2018

Keywords

  • aptamer
  • leukemia
  • lymphoma
  • multiple myeloma
  • precision medicine

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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