Oestrogen receptors and peripheral serum levels of oestradiol-17β in patients with mammary carcinoma

N. O. Theve; K. Carlström; J. Å Gustafsson; S. Gustafsson; B. Nordenskjöld; H. Sköldefors; Ö Wrange

doi:10.1016/0014-2964(78)90115-9

Oestrogen receptors and peripheral serum levels of oestradiol-17β in patients with mammary carcinoma

N. O. Theve, K. Carlström, J. Å Gustafsson, S. Gustafsson, B. Nordenskjöld, H. Sköldefors, Ö Wrange

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Abstract

Oestradiol receptors were determined by isoelectric focusing in cytosol from breast cancer tissue from 12 pre- and 70 postmenopausal patients. Simultaneous determination of the peripheral serum levels of oestradiol-17β was carried out in the 12 premenopausal and 57 of the postmenopausal patients. At oestradiol-17β levels below 150 pM the receptor values ranged from below 0.01 to 7.19 fmole bound [³H] oestradiol-17β/μg of DNA. At oestradiol-17β levels above 150 pM only low receptor values (<0.25 fmole bound [³H] oestradiol-17β/μg of DNA) were recorded. The results indicate an influence of the endogenous oestrogen on the receptor assay probably due to blockade of the hormone binding site. It is proposed that an endocrine evaluation of the patient should be performed together with the oestrogen receptor assay.

Original language	English (US)
Pages (from-to)	1337-1340
Number of pages	4
Journal	European Journal of Cancer (1965)
Volume	14
Issue number	12
DOIs	https://doi.org/10.1016/0014-2964(78)90115-9
State	Published - Dec 1978

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Medicine(all)

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title = "Oestrogen receptors and peripheral serum levels of oestradiol-17β in patients with mammary carcinoma",

abstract = "Oestradiol receptors were determined by isoelectric focusing in cytosol from breast cancer tissue from 12 pre- and 70 postmenopausal patients. Simultaneous determination of the peripheral serum levels of oestradiol-17β was carried out in the 12 premenopausal and 57 of the postmenopausal patients. At oestradiol-17β levels below 150 pM the receptor values ranged from below 0.01 to 7.19 fmole bound [3H] oestradiol-17β/μg of DNA. At oestradiol-17β levels above 150 pM only low receptor values (<0.25 fmole bound [3H] oestradiol-17β/μg of DNA) were recorded. The results indicate an influence of the endogenous oestrogen on the receptor assay probably due to blockade of the hormone binding site. It is proposed that an endocrine evaluation of the patient should be performed together with the oestrogen receptor assay.",

author = "Theve, {N. O.} and K. Carlstr{\"o}m and Gustafsson, {J. {\AA}} and S. Gustafsson and B. Nordenskj{\"o}ld and H. Sk{\"o}ldefors and {\"O} Wrange",

note = "Funding Information: Accepted 26 April 1978. *This investigation was supported by grants from Cancert~ireningen i Stockholm (to J.-~. G.) and from Riksl~renin~en mot Cancer (to B. N.J. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "1978",

month = dec,

doi = "10.1016/0014-2964(78)90115-9",

language = "English (US)",

volume = "14",

pages = "1337--1340",

journal = "European Journal of Cancer (1965)",

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T1 - Oestrogen receptors and peripheral serum levels of oestradiol-17β in patients with mammary carcinoma

AU - Theve, N. O.

AU - Carlström, K.

AU - Gustafsson, J. Å

AU - Gustafsson, S.

AU - Nordenskjöld, B.

AU - Sköldefors, H.

AU - Wrange, Ö

N1 - Funding Information: Accepted 26 April 1978. *This investigation was supported by grants from Cancert~ireningen i Stockholm (to J.-~. G.) and from Riksl~renin~en mot Cancer (to B. N.J. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 1978/12

Y1 - 1978/12

N2 - Oestradiol receptors were determined by isoelectric focusing in cytosol from breast cancer tissue from 12 pre- and 70 postmenopausal patients. Simultaneous determination of the peripheral serum levels of oestradiol-17β was carried out in the 12 premenopausal and 57 of the postmenopausal patients. At oestradiol-17β levels below 150 pM the receptor values ranged from below 0.01 to 7.19 fmole bound [3H] oestradiol-17β/μg of DNA. At oestradiol-17β levels above 150 pM only low receptor values (<0.25 fmole bound [3H] oestradiol-17β/μg of DNA) were recorded. The results indicate an influence of the endogenous oestrogen on the receptor assay probably due to blockade of the hormone binding site. It is proposed that an endocrine evaluation of the patient should be performed together with the oestrogen receptor assay.

AB - Oestradiol receptors were determined by isoelectric focusing in cytosol from breast cancer tissue from 12 pre- and 70 postmenopausal patients. Simultaneous determination of the peripheral serum levels of oestradiol-17β was carried out in the 12 premenopausal and 57 of the postmenopausal patients. At oestradiol-17β levels below 150 pM the receptor values ranged from below 0.01 to 7.19 fmole bound [3H] oestradiol-17β/μg of DNA. At oestradiol-17β levels above 150 pM only low receptor values (<0.25 fmole bound [3H] oestradiol-17β/μg of DNA) were recorded. The results indicate an influence of the endogenous oestrogen on the receptor assay probably due to blockade of the hormone binding site. It is proposed that an endocrine evaluation of the patient should be performed together with the oestrogen receptor assay.

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Oestrogen receptors and peripheral serum levels of oestradiol-17β in patients with mammary carcinoma

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