Oestrogen Receptors

Rodrigo P.A. Barros, Jan Åke Gustafsson

Research output: Contribution to journalArticle

Abstract

The birth of nuclear receptors took place at the end of the 1950s when Elwood Jensen discovered specific binding of tritium-labelled oestradiol-17β in the uterus, a known target of oestrogens. Over the following years, Jensen and collaborators, e.g. Jacobsen and Gorski, identified the oestradiolconcentrating mechanism as a high-affinity low-capacity soluble receptor which was termed the ER (oestrogen receptor)1

Original languageEnglish (US)
JournalBiochemist
Volume31
Issue number2
DOIs
StatePublished - 2009

Keywords

  • DNA
  • insulin resistance
  • ligand
  • nuclear
  • oestrogen
  • receptor
  • steroid

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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