Ocular chrysiasis correlated with gold concentrations in the crystalline lens during chrysotherapy

Norman L. Gottlieb, James C. Major

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

The eyes of 11 patients with rheumatoid arthritis (RA) who received extended chrysotherapy (mean cumulative dose greater than 7 grams during a mean 6-year period) were examined biomicroscopically. Minute reddish-purple particles were seen in the cornea (corneal chrysiasis) in 5 and in the lens (lens chrysiasis) in 4 patients. Particulate deposits were absent in 11 other RA patients who had not received gold treatment. Seven crystalline lenses from 5 gold-treated patients were removed surgically because of incidental cataract formation and analyzed for gold content using neutron activation analysis. Although the mean lens gold concentration was higher in these patients than in non-gold-treated controls without RA (0.0073 μg/grams versus 0.001 μg/grams), the absolute gold level was markedly lower than that found in 25 diverse tissues analyzed previously. This finding is compatible with the absence of clinical gold-related lens disease or visual impairment.

Original languageEnglish (US)
Pages (from-to)704-708
Number of pages5
JournalArthritis & Rheumatism
Volume21
Issue number6
DOIs
StatePublished - 1978

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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