OCIAD1 contributes to neurodegeneration in Alzheimer’s disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages

Xuping Li, Lin Wang, Matthew D. Cykowski, Tiancheng He, Timothy Liu, Joshua Chakranarayan, Andreana Rivera, Hong Zhao, Suzanne Zein-Eldin Powell, Weiming Xia, Stephen T. Wong

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Background: Hyperamyloidosis in the brain is known as the earliest neuropathological change and a unique etiological factor in Alzheimer's disease (AD), while progressive neurodegeneration in certain vulnerable brain regions forms the basis of clinical syndromes. It is not clear how early hyperamyloidosis is implicated in progressive neurodegeneration and what factors contribute to the selective brain vulnerability in AD. Methods: Bioinformatics and experimental neurobiology methods were integrated to identify novel factors involved in the hyperamyloidosis-induced brain vulnerability in AD. We first examined neurodegeneration-specific gene signatures from sporadic AD patients and synaptic protein changes in young transgenic AD mice. Then, we systematically assessed the association of a top candidate gene with AD and investigated its mechanistic role in neurodegeneration. Findings: We identified the ovary-orientated protein OCIAD1 (Ovarian-Carcinoma-Immunoreactive-Antigen-Domain-Containing-1) as a neurodegeneration-associated factor for AD. Higher levels of OCIAD1, found in vulnerable brain areas and dystrophic neurites, were correlated with disease severity. Multiple early AD pathological events, particularly Aβ/GSK-3β signaling, elevate OCIAD1, which in turn interacts with BCL-2 to impair mitochondrial function and facilitates mitochondria-associated neuronal injury. Notably, elevated OCIAD1 by Aβ increases cell susceptibility to other AD pathological challenges. Interpretation: Our findings suggest that OCIAD1 contributes to neurodegeneration in AD by impairing mitochondria function, and subsequently leading to neuronal vulnerability, and synaptic damages. Funding: Ting Tsung & Wei Fong Chao Foundation, John S Dunn Research Foundation, Cure Alzheimer's Fund, and NIH R01AG057635 to STCW.

Original languageEnglish (US)
Article number102569
StatePublished - Jan 2020


  • Alzheimer's disease
  • Hyperamyloidosis
  • Mitochondrial dysfunction
  • Neurodegeneration
  • OCIAD1
  • Protein Aggregates
  • Up-Regulation
  • Caspase 3/metabolism
  • Humans
  • Mitochondria/pathology
  • Tumor Suppressor Protein p53/metabolism
  • Synapses/pathology
  • Brain/pathology
  • Cell Death
  • Membrane Potential, Mitochondrial
  • Neoplasm Proteins/metabolism
  • Amyloid beta-Peptides/metabolism
  • Glycogen Synthase Kinase 3 beta/metabolism
  • Mice, Transgenic
  • Animals
  • Neurons/metabolism
  • Protein Binding
  • Nerve Degeneration/metabolism
  • F-Box Proteins/metabolism
  • Mice
  • Enzyme Activation
  • Proto-Oncogene Proteins c-bcl-2/metabolism
  • Alzheimer Disease/metabolism

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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