Obesity-associated breast inflammation among Hispanic/Latina breast cancer patients

Heather Greenlee, Zaixing Shi, Hanina Hibshoosh, Dilip D. Giri, Aqeel Ahmed, Samantha Williams, Domenick J. Falcone, Lisle A. Winston, Xi K. Zhou, Clifford A. Hudis, Dawn L. Hershman, Andrew Dannenberg, Neil M. Iyengar

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Breast white adipose tissue inflammation (BWATi) is associated with obesity and higher breast cancer risk among non-Hispanic white women. Obesity is prevalent in Hispanic/Latina patients with breast cancer, and the occurrence of BWATi in this population is not well-characterized. The association between BWATi and body mass index (BMI) was evaluated in Hispanic/ Latina patients with breast cancer who underwent mastectomy. BWATi was defined as the presence of crown-like structures of the breast (CLS-B), detected by CD68 IHC in nontumor breast tissue. BWATi severity was quantified as number of CLS-B/cm 2 . Adipocyte diameter was measured using hematoxylin and eosin-stained breast tissue sections. Preoperative BMI (within 1 week prior to mastectomy) was categorized as normal (18.5–<25.0 kg/m 2 ), overweight (25.0–<30.0 kg/m 2 ), class I obesity (30.0–<35.0 kg/m 2 ), and class II–III obesity (35.0 kg/m 2 or above). Patient charts were abstracted to record clinicopathologic features and liver function tests <90 days before mastectomy. The study included 91 women (mean age 69 years; range 36–96 years). Prevalence of BWATi increased with BMI (24% in normal weight, 34% in overweight, 57% in class I obesity, and 65% in class II–III obesity; P trend <0.01). Severe BWATi (>0.27 CLS-B/cm 2 ) was associated with higher BMI (P trend ¼ 0.046) and greater adipocyte diameter (P ¼ 0.04). Adjusting for BMI, neoadjuvant chemotherapy, and elevated alanine aminotransferase were associated with severe BWATi, and current smoking was associated with mild BWATi (all P < 0.05). BWATi was associated with higher BMI in Hispanic/Latina patients with breast cancer, consistent with previously described associations in other populations.

Original languageEnglish (US)
Pages (from-to)21-30
Number of pages10
JournalCancer Prevention Research
Issue number1
StatePublished - Jan 2019

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Obesity-associated breast inflammation among Hispanic/Latina breast cancer patients'. Together they form a unique fingerprint.

Cite this