Obesity and disturbed lipoprotein profile in estrogen receptor-α-deficient male mice

Claes Ohlsson, Nina Hellberg, Paolo Parini, Olle Vidal, Mohammed Bohlooly, Mats Rudling, Marie K. Lindberg, Margaret Warner, Bo Angelin, Jan Åke Gustafsson

Research output: Contribution to journalArticle

260 Scopus citations

Abstract

Clinical case reports have documented disturbances of carbohydrate and lipid metabolism in aromatase deficient and estrogen resistant males. The aim of the present study was to explore the metabolic functions of estrogens in male mice and to dissect the estrogen receptor (ER) specificity of such effects. Total body fat content and serum levels of leptin were followed in ERα knockout (ERKO), ERβ knockout (BERKO), and ERα/β double knockout (DERKO) mice. Neither the total body fat nor serum leptin levels were altered in any group before or during sexual maturation. However, after sexual maturation ERKO and DERKO, but not BERKO, demonstrated a clear increase in total body fat and enhanced serum leptin levels. Serum cholesterol was increased and a qualitative change in the lipoprotein profile, including smaller LDL particles, was observed in ERKO and DERKO mice. In conclusion, ERα but not ERβ-inactivated male mice develop obesity after sexual maturation. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)640-645
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume278
Issue number3
DOIs
StatePublished - Nov 30 2000

Keywords

  • Cholesterol
  • Dual energy X-ray absorptiometry
  • Leptin
  • Lipoprotein profile
  • Transgenic

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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