Obesity and cancer: Local and systemic mechanisms

Neil M. Iyengar, Clifford A. Hudis, Andrew J. Dannenberg

Research output: Contribution to journalArticle

129 Scopus citations

Abstract

Obesity is a leading modifiable risk factor for the development of several epithelial malignancies. In addition to increasing risk, obesity also confers worse prognosis for many cancers. Obesity represents an overall state of energy imbalance frequently associated with systemic effects including insulin resistance, altered hormone signaling, and high circulating levels of proinflammatory mediators. In addition to its systemic effects, obesity causes subclinical white adipose inflammation including increased tissue levels of proinflammatory mediators. Both local and systemic effects are likely to contribute to the development and progression of cancer. An understanding of the interplay between local and systemic alterations involved in the obesity-cancer link provides the basis for developing interventions aimed at mitigating the protumorigenic effects.

Original languageEnglish (US)
Pages (from-to)297-309
Number of pages13
JournalAnnual Review of Medicine
Volume66
DOIs
StatePublished - Jan 14 2015

Keywords

  • adipocytes
  • adipose tissue
  • body mass index
  • cancer risk
  • inflammation
  • insulin resistance
  • macrophages
  • metabolic syndrome

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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