Numerical simulation of magnetic resonance angiographies of an anatomically realistic stenotic carotid bifurcation

Sylvie Lorthois, Jenn Stroud-Rossman, Stanley Berger, Liang Der Jou, David Saloner

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Magnetic Resonance Angiography (MRA) has become a routine imaging modality for the clinical evaluation of obstructive vascular disease. However, complex circulatory flow patterns, which redistribute the Magnetic Resonance (MR) signal in a complicated way, may generate flow artifacts and impair image quality. Numerical simulation of MRAs is a useful tool to study the mechanisms of artifactual signal production. The present study proposes a new approach to perform such simulations, applicable to complex anatomically realistic vascular geometries. Both the Navier-Stokes and the Bloch equations are solved on the same mesh to obtain the distribution of modulus and phase of the magnetization. The simulated angiography is subsequently constructed by a simple geometric procedure mapping the physical plane into the MRA image plane. Steady bidimensional numerical simulations of MRAs of an anatomically realistic severely stenotic carotid artery bifurcation are presented, for both time-of-flight and contrast-enhanced imaging modalities. These simulations are validated by qualitative comparison with flow phantom experiments performed under comparable conditions.

Original languageEnglish (US)
Pages (from-to)270-283
Number of pages14
JournalAnnals of Biomedical Engineering
Volume33
Issue number3
DOIs
StatePublished - Mar 2005

Keywords

  • Angiography
  • Bloch equations
  • Carotid stenoses
  • Computer simulation
  • Flow artifacts
  • Magnetic resonance

ASJC Scopus subject areas

  • Biomedical Engineering

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