Numerical modeling of drug delivery in organs: From CT scans to FE model

Miljan Milosevic, Vladimir Simic, Milos Kojic

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Mass transport within an organ is complex process which occurs through two different domains: networks of blood vessels and surrounding tissue. Consequently, development of a comprehensive transport model remains a challenge. In this paper we showed an application of a recently introduced multi-scale transport model [1, 2], where larger vessels are modeled by simple 1D finite elements. This model couples convective and diffusive transport within complex system consisted of capillaries and tissue, where connection between these fluid (capillaries) and solid (tissue) domains is accomplished by using fictitious 1D elements. In order to apply the developed model, a reconstruction procedure, consisted of: segmentation, skeletonization using augmented FMM method, and diameter recognition within indoor software, is processed. At the end, numerical simulations are performed in order to get the pressure and concentration distribution in the vessel network and surrounding tissue, showed by examples presented in the paper.

Original languageEnglish (US)
Title of host publicationPervasive Computing Paradigms for Mental Health - Selected Papers from MindCare 2016, Fabulous 2016, and IIoT 2015
EditorsNenad Filipovic, Pietro Cipresso, Liljana Gavrilovska, Aleksandar Matic, Silvia Serino, Nuria Oliver
PublisherSpringer-Verlag
Pages87-92
Number of pages6
ISBN (Print)9783319749341
DOIs
StatePublished - 2018
EventInternational Symposium on Pervasive Computing Paradigms for Mental Health - MindCare,2016 - Barcelona, Spain
Duration: Nov 28 2016Nov 29 2016

Publication series

NameLecture Notes of the Institute for Computer Sciences, Social-Informatics and Telecommunications Engineering, LNICST
Volume207
ISSN (Print)1867-8211

Other

OtherInternational Symposium on Pervasive Computing Paradigms for Mental Health - MindCare,2016
CountrySpain
CityBarcelona
Period11/28/1611/29/16

Keywords

  • Finite element method
  • Liver model
  • Pancreas model
  • Pipe finite element
  • Segmentation
  • Skeletonization

ASJC Scopus subject areas

  • Computer Networks and Communications

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