Nucleic Acid Delivery for Endothelial Dysfunction in Cardiovascular Diseases

Dipti Deshpande, David R Janero, Victor Segura-Ibarra, Elvin Blanco, Mansoor M Amiji

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Endothelial dysfunction has been implicated in the pathophysiology of multiple cardiovascular diseases and involves components of both innate and acquired immune mechanisms. Identifying signature patterns and targets associated with endothelial dysfunction can help in the development of novel nanotherapeutic platforms for treatment of vascular diseases. This review discusses nucleic acid-based regulation of endothelial function and the different nucleic acid-based nanotherapeutic approaches designed to target endothelial dysfunction in cardiovascular disorders.

Original languageEnglish (US)
Pages (from-to)134-140
Number of pages7
JournalMethodist DeBakey cardiovascular journal
Volume12
Issue number3
DOIs
StatePublished - Sep 2016

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