Nuclear Receptors in Cancer Inflammation and Immunity

Linjie Zhao, Hongbo Hu, Jan Åke Gustafsson, Shengtao Zhou

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Members of the nuclear receptor (NR) superfamily orchestrate cellular processes that can impact on numerous cancer hallmarks. NR activity plays important roles in the tumor microenvironment by controlling inflammation and immune responses. We summarize recent insights into the diverse mechanisms by which NR activity can control tumor inflammation, the roles of different NRs in modulating tumor immunity, and the biological features of immune cells that express specific NRs in the context of cancer. NR-dependent alterations in tumor inflammation and immunity may be amenable to pharmacological manipulation and offer new clues regarding the development of novel cancer therapeutic regimens.

Original languageEnglish (US)
Pages (from-to)172-185
Number of pages14
JournalTrends in Immunology
Issue number2
StatePublished - Feb 2020


  • Humans
  • Inflammation/immunology
  • Neoplasms/immunology
  • Receptors, Cytoplasmic and Nuclear/immunology
  • Signal Transduction
  • Tumor Microenvironment/immunology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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