@article{c107beb58af74280ae1b469d52388c37,
title = "Nuclear Receptors in Cancer Inflammation and Immunity",
abstract = "Members of the nuclear receptor (NR) superfamily orchestrate cellular processes that can impact on numerous cancer hallmarks. NR activity plays important roles in the tumor microenvironment by controlling inflammation and immune responses. We summarize recent insights into the diverse mechanisms by which NR activity can control tumor inflammation, the roles of different NRs in modulating tumor immunity, and the biological features of immune cells that express specific NRs in the context of cancer. NR-dependent alterations in tumor inflammation and immunity may be amenable to pharmacological manipulation and offer new clues regarding the development of novel cancer therapeutic regimens.",
author = "Linjie Zhao and Hongbo Hu and Gustafsson, {Jan {\AA}ke} and Shengtao Zhou",
note = "Funding Information: We thank Dr Ryan C. Gimple from the Department of Medicine, Division of Regenerative Medicine, University of California San Diego, USA for polishing the language of this manuscript. This work was supported by grants from the National Natural Science Foundation of China (81822034, 81821002, 81773119, 81402396, 91740111, and 81871232), the National Key Research and Development Program of China (2017YFA0106800, 2018YFA0109200, and 2016YFA0502203), the Sichuan Science-Technology International Cooperation Project (grant 2019YFH0144), and Direct Scientific Research Grants from West China Second Hospital, Sichuan University (grants KS021 and K1907). J.A.G. is thankful to the Robert A. Welch Foundation for a grant (E-0004), the Brockman Foundation, the Swedish Cancer Foundation, the Center for Innovative Medicine, and the Novo Nordisk Fund. Funding Information: We thank Dr Ryan C. Gimple from the Department of Medicine, Division of Regenerative Medicine, University of California San Diego, USA for polishing the language of this manuscript. This work was supported by grants from the National Natural Science Foundation of China ( 81822034 , 81821002 , 81773119 , 81402396 , 91740111 , and 81871232 ), the National Key Research and Development Program of China ( 2017YFA0106800 , 2018YFA0109200 , and 2016YFA0502203 ), the Sichuan Science-Technology International Cooperation Project (grant 2019YFH0144 ), and Direct Scientific Research Grants from West China Second Hospital, Sichuan University (grants KS021 and K1907 ). J.A.G. is thankful to the Robert A. Welch Foundation for a grant ( E-0004 ), the Brockman Foundation , the Swedish Cancer Foundation , the Center for Innovative Medicine , and the Novo Nordisk Fund . Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2020",
month = feb,
doi = "10.1016/j.it.2019.12.006",
language = "English (US)",
volume = "41",
pages = "172--185",
journal = "Trends in Immunology",
issn = "1471-4906",
publisher = "Elsevier Limited",
number = "2",
}