Nuclear factor-κ B repression in antiinflammation and immunosuppression by glucocorticoids

Bart Van Der Burg, Johan Liden, Sam Okret, Franck Delaunay, Sacha Wissink, Paul T. Van Der Saag, Jan Åke Gustafsson

    Research output: Contribution to journalReview articlepeer-review

    54 Scopus citations

    Abstract

    The transcription factor nuclear factor-κB (NF-κB) directs transcription of a large number of key molecules in immunological and inflammatory responses. The recently discovered inhibition of transcriptional activity of this factor by the activated glucocorticoid receptor (GR) provides a molecular basis for the potent antiinflammatory and immunosuppressive properties of glucocorticoids. This repressive activity of the GR can function independently of transcriptional activity. Because it has been shown that certain steroid receptor ligands can differentially address transactivation and transrepression functions, it may be possible to develop ligands that specifically suppress NF-κB activity and, as a result, are more efficient in treatment of a variety of important chronic inflammatory diseases with less severe side effects than those of currently available drugs.

    Original languageEnglish (US)
    Pages (from-to)152-157
    Number of pages6
    JournalTrends in Endocrinology and Metabolism
    Volume8
    Issue number4
    DOIs
    StatePublished - 1997

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

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