Nuclear factor-κ B repression in antiinflammation and immunosuppression by glucocorticoids

Bart Van Der Burg, Johan Liden, Sam Okret, Franck Delaunay, Sacha Wissink, Paul T. Van Der Saag, Jan Åke Gustafsson

Research output: Contribution to journalReview article

49 Scopus citations

Abstract

The transcription factor nuclear factor-κB (NF-κB) directs transcription of a large number of key molecules in immunological and inflammatory responses. The recently discovered inhibition of transcriptional activity of this factor by the activated glucocorticoid receptor (GR) provides a molecular basis for the potent antiinflammatory and immunosuppressive properties of glucocorticoids. This repressive activity of the GR can function independently of transcriptional activity. Because it has been shown that certain steroid receptor ligands can differentially address transactivation and transrepression functions, it may be possible to develop ligands that specifically suppress NF-κB activity and, as a result, are more efficient in treatment of a variety of important chronic inflammatory diseases with less severe side effects than those of currently available drugs.

Original languageEnglish (US)
Pages (from-to)152-157
Number of pages6
JournalTrends in Endocrinology and Metabolism
Volume8
Issue number4
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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