NR4A subfamily

Weidong Le, Jie Dong, Sheng Chen

Research output: Chapter in Book/Report/Conference proceedingChapter


The NR4A subfamily includes three members, Nur77, Nurr1, and NOR-1, which belong to orphan nuclear receptor superfamily. These factors play essential roles in cell proliferation, growth, differentiation, and apoptosis. Furthermore, dysregulation of these factors has been implicated in several human diseases, such as Parkinson’s disease, immunological diseases, vascular disease and tumor. In this article, we will review the structure and functions of these factors as well as their relationship with diseases.

Original languageEnglish (US)
Title of host publicationThe Curated Reference Collection in Neuroscience and Biobehavioral Psychology
PublisherElsevier Science Ltd.
Number of pages5
ISBN (Electronic)9780128093245
StatePublished - Jan 1 2016


  • Dopamine
  • NOR-1
  • Nur77
  • Nurr1
  • Parkinson’s disease

ASJC Scopus subject areas

  • Medicine(all)


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