Nr4a orphan receptors as drug targets

Stephen Safe, Syng Ook Lee, Cong Meng, Beiyan Zhou

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The orphan receptor NR4Al (Nur77, TR3, NGFI-B) is overexpressed in many different cancer cell lines and tumors, and, in leukemia cells, NR4Al is also more highly expressed than in B- or T-cell. In contrast, we observed the opposite pattern of NR4A2 (Nurrl) expression in these same cells. NR4Al is primarily oncogenic in cancer cell lines and is a target for inhibitors or inactivators and treatment of Jurkat cells with an NR4Al inactivator-induced apoptosis and inhibited cell growth. The in vitro characterization of NR4Al as pro-oncogenic in leukemia cells is in contrast to the tumor suppressor-like activity of NR4Al in transgenic mouse models, and these differences are currently being investigated.

Original languageEnglish (US)
Title of host publicationTargeted Therapy of Acute Myeloid Leukemi
PublisherSpringer New York
Pages509-528
Number of pages20
ISBN (Electronic)9781493913930
ISBN (Print)9781493913923
DOIs
StatePublished - Jan 1 2015

Keywords

  • Leukemia cell
  • NR4A receptors
  • NR4A1 NR4A2
  • NR4A3
  • Oncogenic
  • Overexpression

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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