Novel therapies for heart failure: focus on anti-inflammatory strategies.

Kumudha Ramasubbu, Guilherme Oliveira, Guillermo Torre

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

The understanding of the pathomechanisms leading to heart failure has evolved from the simplistic pump-failure concept to the more complex syndrome involving neurohormonal and inflammatory systems. Anti-inflammatory therapy targeting specific cytokines, however, such as tumor necrosis factor-alpha, has failed to show clinical benefit. As a result, the focus has turned toward more broad-spectrum anti-inflammatory strategies. This review examines the various broad-spectrum anti-inflammatory modalities that have been used in heart failure: IV immunoglobulin administration, immune modulation therapy, immune adsorption, and plasmapheresis.

Original languageEnglish (US)
JournalCongestive heart failure (Greenwich, Conn.)
Volume12
Issue number3
StatePublished - Jan 1 2006

ASJC Scopus subject areas

  • Emergency Medicine
  • Emergency
  • Cardiology and Cardiovascular Medicine

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