TY - JOUR
T1 - Novel therapies for heart failure
T2 - focus on anti-inflammatory strategies.
AU - Ramasubbu, Kumudha
AU - Oliveira, Guilherme
AU - Torre, Guillermo
PY - 2006/1/1
Y1 - 2006/1/1
N2 - The understanding of the pathomechanisms leading to heart failure has evolved from the simplistic pump-failure concept to the more complex syndrome involving neurohormonal and inflammatory systems. Anti-inflammatory therapy targeting specific cytokines, however, such as tumor necrosis factor-alpha, has failed to show clinical benefit. As a result, the focus has turned toward more broad-spectrum anti-inflammatory strategies. This review examines the various broad-spectrum anti-inflammatory modalities that have been used in heart failure: IV immunoglobulin administration, immune modulation therapy, immune adsorption, and plasmapheresis.
AB - The understanding of the pathomechanisms leading to heart failure has evolved from the simplistic pump-failure concept to the more complex syndrome involving neurohormonal and inflammatory systems. Anti-inflammatory therapy targeting specific cytokines, however, such as tumor necrosis factor-alpha, has failed to show clinical benefit. As a result, the focus has turned toward more broad-spectrum anti-inflammatory strategies. This review examines the various broad-spectrum anti-inflammatory modalities that have been used in heart failure: IV immunoglobulin administration, immune modulation therapy, immune adsorption, and plasmapheresis.
UR - http://www.scopus.com/inward/record.url?scp=33746050783&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746050783&partnerID=8YFLogxK
M3 - Review article
C2 - 16760701
AN - SCOPUS:33746050783
SN - 1527-5299
VL - 12
JO - Congestive heart failure (Greenwich, Conn.)
JF - Congestive heart failure (Greenwich, Conn.)
IS - 3
ER -