Novel parameters of global and regional mitral annulus geometry in man: Comparison between normals and organic mitral regurgitation, before and after mitral valve repair

S. Ben Zekry, S. Jain, S. K. Alexander, Y. Li, A. Aggarwal, A. Jajoo, S. H. Little, G. M. Lawrie, R. Azencott, W. A. Zoghbi

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Aims The mitral annulus (MA) saddle shape is complex but vital for a normal functioning mitral apparatus. Although conventional parameters of MA geometry such as area and height are helpful, they fall short of describing its complex regional geometry. Methods and results In this prospective study, novel parameters of MA curvature and torsion were derived from three-dimensional (3D) transoesophageal echocardiography. These quantitative indices were computed in 15 patients with normal valves (age 53 ± 8 years) and in 15 patients with organic significant mitral regurgitation (MR, age 66 ± 11 years), before and after mitral valve repair (MVR). The MA was traced and modelled in mid- and end-systole. Curvature and torsion were computed at 500 points across the MA to derive regional and global indices. Overall, patients with organic MR presented the smallest global curvature and torsion; this decrease in curvature and torsion reflects a loss of tonicity of the MA tissue. These changes were largely corrected with MVR surgery, to higher values, compared with normals. The regional analysis revealed similar trends. The maximal MA curvature was found to be at the MA 'anterior horn', whereas the MA 'posterior horn' had the lowest curvature values. Conclusion Novel MA parameters of curvature and torsion can be computed from 3D echocardiography and provide quantitative characteristics of dynamic regional MA geometry. In patients with organic MR, the reduced regional and global curvatures improve following surgical MVR. These quantitative parameters may help further refine the quantitative description of MA geometry in various mitral valve pathologies and after MVR.

Original languageEnglish (US)
Pages (from-to)447-457
Number of pages11
JournalEuropean Heart Journal Cardiovascular Imaging
Volume17
Issue number4
DOIs
StatePublished - Apr 1 2016

Keywords

  • Mitral annulus
  • Mitral valve repair
  • Organic mitral regurgitation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

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