Novel osteointegrative sr-substituted apatitic cements enriched with Alginate

Simone Sprio, Massimiliano Dapporto, Monica Montesi, Silvia Panseri, Wanda Lattanzi, Enrico Pola, Giandomenico Logroscino, Anna Tampieri

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The present work describes the synthesis of novel injectable, self-setting bone cements made of strontium-substituted hydroxyapatite (Sr-HA), obtained by single-phase calcium phosphate precursors doped with different amounts of strontium and enriched with alginate. The addition of alginate improved the injectability, cohesion, and compression strength of the cements, without affecting the hardening process. A Sr-HA cement exhibiting adequate hardening times and mechanical strength for clinical applications was further tested in vivo in a rabbit model, in comparison with a commercial calcium phosphate cement, revealing the maintenance of biomimetic composition and porous microstructure even after one month in vivo, as well as enhanced ability to induce new bone formation and penetration.

Original languageEnglish (US)
Pages (from-to)1-17
Number of pages17
JournalMaterials
Volume9
Issue number9
DOIs
StatePublished - Sep 2016

Keywords

  • Alginate
  • Bone cement
  • Hydroxyapatite
  • In vivo
  • Osteointegration
  • Strontium

ASJC Scopus subject areas

  • Materials Science(all)

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