Abstract
HUNDREDS of murine dilute mutations have been identified and analysed, making dilute one of the best genetically characterized of all mammalian loci. The recessive dilute (d) coat colour muta-tion carried by many inbred strains of mice produces a lightening of coat colour, caused by an abnormal adendritic melanocyte morphology that results in an uneven release of pigment granules into the developing hair shaft1,2. Most dilute alleles (dilute-lethal) also produce a neurological defect, characterized by convulsions and opisthotonus, apparent at 8-10 days of age and continuing.
Original language | English (US) |
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Pages (from-to) | 709-713 |
Number of pages | 5 |
Journal | Nature |
Volume | 349 |
Issue number | 6311 |
DOIs | |
State | Published - 1991 |
ASJC Scopus subject areas
- General