Novel Multiphase Assessment for Predicting Left Ventricular Outflow Tract Obstruction Before Transcatheter Mitral Valve Replacement

Christopher U. Meduri, Michael J. Reardon, D. Scott Lim, Elliot Howard, Gan Dunnington, David P. Lee, David Liang, Robert Gooley, Daniel O'Hair, Martin K. Ng, Antony Walton, Konstantinos Spargias, Daniel Blackman, Augustin Coisne, David Hildick-Smith, Marine De Gouy, Sharla Chenoweth, Saibal Kar, Patrick M. McCarthy, Nicolo PiazzaAtif Qasam, Randolph P. Martin, Martin B. Leon, Michael J. Mack, David H. Adams, Vinayak Bapat

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Objectives: This study proposes a physiologic assessment of left ventricular outflow tract obstruction (LVOTO) that accommodates changes in systolic flow and accounts for the dynamic neo–left ventricular outflow tract (LVOT). Background: Patients considered for transcatheter mitral valve replacement trials often screen-fail because of the perceived risk of LVOTO. In the Intrepid Global Pilot Study, assumed risk of LVOTO was based on computed tomography estimates of the neo-LVOT area computed at end-systole. However, this may overestimate actual risk. Methods: Retrospective analyses were performed for screen-failed patients for potential LVOTO (n = 33) and treated patients (n = 29) with available dynamic computed tomography. A multiphase assessment of the neo-LVOT area was performed and represented as: 1) multiphase average; and 2) early systolic value. Prospective evaluation was performed in 9 patients approved for enrollment with multiphase and early systole methods that would have previously screen-failed with the end-systolic approach. Results: Of 166 patients screened for possible inclusion; 32 were screen-failed for nonanatomical reasons. Screen failure for assumed LVOTO risk occurred in 37 of 134 (27.6%) patients. Retrospective analysis indicated a potential enrollment increase of 11 of 33 (33.3%) and 18 of 33 (54.5%) patients using multiphase and early systolic assessment methods. In the prospective cohort, there were no clinical observations of LVOTO 30 days post-procedure, despite assumed risk based on end-systolic estimates. Conclusions: Multiphase, and specifically early systolic, assessment of the neo-LVOT may better determine risk of LVOTO with transcatheter mitral valve replacement compared with end-systolic estimates. This novel approach has the potential to significantly increase patient eligibility, with over one-half of patients previously screen-failed now eligible for treatment.

Original languageEnglish (US)
Pages (from-to)2402-2412
Number of pages11
JournalJACC: Cardiovascular Interventions
Issue number23
StatePublished - Dec 9 2019


  • LVOT
  • TMVR
  • left ventricular outflow tract obstruction
  • mitral valve
  • neo-LVOT

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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