Novel mesoporous silicon particles as an efficient sustained delivery system for antibiotics

I. Yazdi, C. Chiappini, Bradley K. Weiner, Mauro Ferrari, Ennio Tasciotti

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

One of major challenges in orthopedics is chronic osteomyelitis infection. Systemic antibiotic therapy is required along with soft tissue and bone debridement in the therapy. The aim of this study was the preparation of biodegradable mesoporous silicon microparticles containing different antibiotics for chronic osteomyelitis produced by bacteria. To optimize the total yield, particle size, surface characteristics, pore size, loading capacity and in vitro release characteristics of the microparticles were demonstrated as well as stability assessment of drug under biological condition. Surface modification provides an efficient and reliable system for controlled release. Microbiological assay was performed using different bacterial strains. Different antibiotics loaded into silicon microparticles were characterized by energy-dispersive X-ray spectroscopy (SEM-EDS), and high performance liquid chromatography (HPLC). Antibiotic-loaded surface modified microparticles resulted to prolonging the release up to one month, depending on surface chemistry and pore sizes. The results of the microbiological assay show that the loading of antibiotics into microparticles is able to enhance the anti-bacterial activity of the drug significantly. These results persuade us to pursue attempts to simplify the management of bone infection without obvious intolerance to the patient.

Original languageEnglish (US)
Title of host publicationNanotechnology 2010
Subtitle of host publicationBio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010
Pages324-325
Number of pages2
StatePublished - 2010
EventNanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010 - Anaheim, CA, United States
Duration: Jun 21 2010Jun 24 2010

Publication series

NameNanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010
Volume3

Other

OtherNanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010
CountryUnited States
CityAnaheim, CA
Period6/21/106/24/10

Keywords

  • Antibiotic
  • Drug delivery
  • Drug release
  • Mesoporous
  • Microparticles
  • Silicon

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Electrical and Electronic Engineering

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