Novel mammalian kinase related to yeast and fly chromosome segregation regulators is exclusively expressed in the germline

Ganesan Gopalan, John Centanni, Debra J. Gilbert, Neal G. Copeland, Nancy A. Jenkins, Peter J. Donovan

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Since kinases play important roles in regulating both mitotic and meiotic cell cycles in a variety of organisms, we sought to clone novel kinases that might regulate germ cell development in mammals. One of the kinases we identified, termed IAK3, is a member of a newly emerging subfamily of the serine/threonine kinase superfamily and mapped to mouse Chromosome 7. This kinase is related to genes identified in yeast and Drosophila which are regulators of chromosome segregation and to another mammalian kinase, IAK1, which is a new component of the centrosome and mitotic spindle. IAK3 transcripts are uniquely expressed in germ cells and are undetectable in proliferating somatic cells. Thus IAK3 may be a regulator of microtubule dynamics and/or chromosome segregation in the germline.

Original languageEnglish (US)
Pages (from-to)18-28
Number of pages11
JournalMolecular Reproduction and Development
Volume52
Issue number1
DOIs
StatePublished - 1999

Keywords

  • Germline
  • Meiosis
  • Murine
  • Oogenesis
  • Serine/threonine kinase
  • Spermatogenesis

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology
  • Cell Biology

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