TY - JOUR
T1 - Novel insights into combating cancer chemotherapy resistance using a plasmonic nanocarrier
T2 - Enhancing drug sensitiveness and accumulation simultaneously with localized mild photothermal stimulus of femtosecond pulsed laser
AU - Wang, Liming
AU - Lin, Xiaoying
AU - Wang, Jing
AU - Hu, Zhijian
AU - Ji, Yinglu
AU - Hou, Shuai
AU - Zhao, Yuliang
AU - Wu, Xiaochun
AU - Chen, Chunying
PY - 2014/7/16
Y1 - 2014/7/16
N2 - Chemotherapy resistance remains a large obstacle to successful clinical cancer therapy, mainly due to little accumulation and low sensitivity of drugs and the effective clinical strategy still lacks. Herein, a novel yet simple strategy to combat cancer drug resistance using the plasmonic feature-based photothermal properties is reported. Rather than directly killing cancer cells using nanoparticle-mediated hyperthermia, for the first time, localized plasmonic heating of gold nanorod at a mild laser power density can modulate the drug-resistance related genes. This photothermal effect triggers higher expression of heat shock factor (HSF-1) trimers and depresses the expression of P-glycoprotein (Pgp) and mutant p53. In turn, both drug accumulation in the breast cancer resistant cells (MCF-7/ADR) and their sensitiveness to drugs can be greatly enhanced. Considering the universality and feasibility of this strategy, it points out a new unique way to challenge drug resistance.
AB - Chemotherapy resistance remains a large obstacle to successful clinical cancer therapy, mainly due to little accumulation and low sensitivity of drugs and the effective clinical strategy still lacks. Herein, a novel yet simple strategy to combat cancer drug resistance using the plasmonic feature-based photothermal properties is reported. Rather than directly killing cancer cells using nanoparticle-mediated hyperthermia, for the first time, localized plasmonic heating of gold nanorod at a mild laser power density can modulate the drug-resistance related genes. This photothermal effect triggers higher expression of heat shock factor (HSF-1) trimers and depresses the expression of P-glycoprotein (Pgp) and mutant p53. In turn, both drug accumulation in the breast cancer resistant cells (MCF-7/ADR) and their sensitiveness to drugs can be greatly enhanced. Considering the universality and feasibility of this strategy, it points out a new unique way to challenge drug resistance.
KW - chemotherapy resistance
KW - drug-resistance
KW - gene modulation
KW - gold nanorods
KW - photothermal effects
KW - plasmonic nanocarriers
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U2 - 10.1002/adfm.201400015
DO - 10.1002/adfm.201400015
M3 - Article
AN - SCOPUS:84904540479
VL - 24
SP - 4229
EP - 4239
JO - Advanced Functional Materials
JF - Advanced Functional Materials
SN - 1616-301X
IS - 27
ER -