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Novel immunotherapeutic approaches to the treatment of urothelial carcinoma

Akhil Muthigi, Arvin K. George, Sam J. Brancato, Piyush K. Agarwal

Research output: Contribution to journalReview articlepeer-review

Abstract

Immunotherapy has long played a role in urothelial cancers with the use of bacille Calmette Guérin (BCG) being a mainstay in the treatment of nonmuscle invasive bladder cancer. Novel therapeutic approaches have not significantly impacted mortality in this population and so a renaissance in immunotherapy has resulted. This includes recombinant BCG, oncolytic viruses, monoclonal antibodies, vaccines, and adoptive T-cell therapy. Herein, we provide a review of the current state of the art and future therapies regarding immunotherapeutic strategies for urothelial carcinoma.

Original languageEnglish (US)
Pages (from-to)203-214
Number of pages12
JournalTherapeutic Advances in Urology
Volume8
Issue number3
DOIs
StatePublished - Jun 2016

Keywords

  • immunotherapy
  • NMIBC
  • urothelial carcinoma

ASJC Scopus subject areas

  • Urology

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