Novel aspects of estrogen action.

J. A. Gustafsson

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


The discovery of a second estrogen receptor, ER beta, in 1996 introduced a new paradigm in our understanding of estrogen action. ER alpha predominates in the uterus and mammary gland, whereas ER beta has significant roles in the central nervous, cardiovascular, and immune systems, urogenital tract, bone, kidney, and lung. ER beta appears to be the only from expressed in the embryonal central nervous system. Photoestrogens may be good candidates for physiologic ligands of ER beta. Coactivator proteins play critical roles in regulating estrogen. Female ER beta-deleted mice (beta ERKO) develop follicular arrest and anovulation.

Original languageEnglish (US)
Pages (from-to)S8-9
JournalJournal of the Society for Gynecologic Investigation
Issue number1 Suppl
StatePublished - 2000

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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