Abstract
Both nitric oxide and asymmetric dimethylarginine (ADMA) play a critical role in the regulation of cerebral blood flow, though their neuroprotective and cytotoxic effects are still under investigation. In this study, we found that nitrate/nitrite (NOx) levels in plasma, ischemic brain tissue, and cerebrospinal fluid (CSF) increased significantly 24 h after 2 h transient middle cerebral artery occlusion (MCAO) in rats. ADMA levels were unchanged in plasma, but decreased significantly in CSF 24 h following MCAO. The CSF ADMA/NOx ratio decreased markedly following ischemia. Rats protected by expression of the chaperonin GroEL or its folding deficient mutant D87K had lower plasma NOx levels at 24 h reperfusion. ADMA, NO, and their ratio in CSF merit further study as biomarkers for ischemic brain injury.
Original language | English (US) |
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Pages (from-to) | 201-204 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 418 |
Issue number | 2 |
DOIs | |
State | Published - May 17 2007 |
Keywords
- ADMA
- CSF
- Focal ischemia
- GroEL
- NO
- Rat
ASJC Scopus subject areas
- General Neuroscience