Normal function of the transcription factor NFAT1 in wasted mice. Chromosome localization of NFAT1 gene

Chun Luo, Neal G. Copeland, Nancy A. Jenkins, Susanne Edelhoff, Christine Disteche, Patrick G. Hogan, Anjana Rao

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

NFAT1 (NFATp), a cytosolic component of the nuclear factor of activated T cells (NFAT), is encoded by a single gene which was mapped to mouse chromosome 2 in the vicinity of the wasted (wst) locus. Although wasted mice display a severe immune disorder, they express normal levels of NFAT1 protein. The NFAT1 protein in wasted mice is properly regulated and possesses comparable DNA binding activity as that in their littermate controls. Therefore, the wasted phenotype is not due to a defect in the expression or early regulation of the NFAT1 protein.

Original languageEnglish (US)
Pages (from-to)29-36
Number of pages8
JournalGene
Volume180
Issue number1-2
DOIs
StatePublished - Nov 21 1996

Keywords

  • Cytokine gene expression
  • DNA-binding protein
  • Genetic diseases
  • RNA splicing
  • T cell activation
  • Transcription regulation

ASJC Scopus subject areas

  • Genetics

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