Normal distribution of lysozyme- and lactoferrin-secreting cells in the chinchilla tubotympanum

Yutaka Hanamure, David J. Lim

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


The distribution of the antibacterial enzyme lysozyme- and lactoferrin-secreting cells in the tubotympanum of normal chinchillas was studied using an immunohistochemical technique. The middle ear mucosa contained lysozyme-secreting cells and lactoferrin-secreting cells. The former were localized primarily in the columnar epithelium area and the latter primarily in the cuboidal epithelium area (that contains serous cells) of the transitional zone. In the eustachian tube, the lysozyme was localized in goblet cells of the mucosal epithelium and mucous cells of the glands, while lactoferrin was localized in serous cells of the glands. Our results indicate that secretory lysozyme and lactoferrin are secreted by different cell types (mucous or serous), supporting the notion of heterogeneity of the secretory cells of the tubotympanum. This finding is consistent with the concept that antibacterial enzyme secretion is an integral part of the normal mucosal defense system in the tubotympanum.

Original languageEnglish (US)
Pages (from-to)410-425
Number of pages16
JournalAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgery
Issue number6
StatePublished - 1986

ASJC Scopus subject areas

  • Otorhinolaryngology


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