Nootropic activity of acetaminophen against colchicine induced cognitive impairment in rats

Vigneshwaran Pitchaimani, Somasundaram Arumugam, Rajarajan A. Thandavarayan, Manisenthilkumar K. Thiyagarajan, Rajasekaran Aiyalu, Remya Sreedhar, Takashi Nakamura, Kenichi Watanabe

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Alzheimer's disease is a devasting neurodegenerative disorder, the most common among the dementing illnesses. Acetaminophen has gaining importance in neurodegenerative diseases by attenuating the dopaminergic neurodegeneration in Caenorhabditis elegans model, decreasing the chemokines and the cytokines and increasing the anti apoptotic protein such as Bcl-2 in neuronal cell culture. The low concentration acetaminophen improved the facilitation to find the hidden platform in Morris Water Maze Test. Also some data suggest that acetaminophen could contribute in neurodegeneration. The present study was aimed to evaluate the effect of acetaminophen against colchicine induced cognitive impairment and oxidative stress in wistar rats. The cognitive learning and memory behaviour was assessed using step through passive avoidance paradigm and acetylcholine esterase activity. The parameters of oxidative stress were assessed by measuring the malondialdehyde, reduced glutathione and catalase levels in the whole brain homogenates. There was a significant memory improvement in the rats received acetaminophen treatment and it has also decreased the acetylcholine esterase enzyme level, confirming its nootropic activity. Acetaminophen neither increases nor decreases the reduced glutathione and catalase in the whole brain homogenates, showing that acetaminophen is devoid of any adverse effect on brain antioxidant defense system.

Original languageEnglish (US)
Pages (from-to)241-244
Number of pages4
JournalJournal of Clinical Biochemistry and Nutrition
Issue number3
StatePublished - May 2012


  • Acetaminophen
  • Alzheimer's disease
  • Colchicine
  • Learning and memory

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry


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