Nonmelanoma Skin Cancer in Patients Older Than Age 85 Years Presenting for Mohs Surgery: A Prospective, Multicenter Cohort Study

Amanda Maisel-Campbell, Katherine A. Lin, Sarah A. Ibrahim, Bianca Y. Kang, Noor Anvery, McKenzie A. Dirr, Rachel E. Christensen, Juliet L. Aylward, Omar Bari, Hamza Bhatti, Diana Bolotin, Basil S. Cherpelis, Joel L. Cohen, Sean Condon, Sheila Farhang, Bahar Firoz, Algin B. Garrett, Roy G. Geronemus, Nicholas J. Golda, Tatyana R. HumphreysEva A. Hurst, Oren H. Jacobson, S. Brian Jiang, Pritesh S. Karia, Arash Kimyai-Asadi, David J. Kouba, James G. Lahti, Martha Laurin Council, Marilyn Le, Deborah F. MacFarlane, Ian A. Maher, Stanley J. Miller, Eduardo K. Moioli, Meghan Morrow, Julia Neckman, Timothy Pearson, Samuel R. Peterson, Christine Poblete-Lopez, Chad L. Prather, Jennifer S. Ranario, Ashley G. Rubin, Chrysalyne D. Schmults, Andrew M. Swanson, Christopher Urban, Y. Gloria Xu, Murad Alam, Simon Yoo, Emily Poon, Vishnu Harikumar, Alexandra Weil, Sanjana Iyengar, Matthew R. Schaeffer

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


IMPORTANCE: It has been suggested that Mohs surgery for skin cancer among individuals with limited life expectancy may be associated with needless risk and discomfort, along with increased health care costs.

OBJECTIVE: To investigate patient- and tumor-specific indications considered by clinicians for treatment of nonmelanoma skin cancer in older individuals.

DESIGN, SETTING, AND PARTICIPANTS: This multicenter, prospective cohort study was conducted using data from US private practice and academic centers. Included patients were those older than age 85 years presenting for skin cancer surgery and referred for Mohs surgery, with reference groups of those younger than age 85 years receiving Mohs surgery and those older than age 85 years not receiving Mohs surgery. Data were analyzed from November 2018 through January 2019.

EXPOSURES: Mohs surgery for nonmelanoma skin cancer.

MAIN OUTCOMES AND MEASURES: Reason for treatment selection.

RESULTS: Among 1181 patients older than age 85 years referred for Mohs surgery (724 [61.9%] men among 1169 patients with sex data; 681 individuals aged >85 to 88 years [57.9%] among 1176 patients with age data) treated at 22 sites, 1078 patients (91.3%) were treated by Mohs surgery, and 103 patients (8.7%) received alternate treatment. Patients receiving Mohs surgery were more likely to have tumors on the face (738 patients [68.5%] vs 26 patients [25.2%]; P < .001) and nearly 4-fold more likely to have high functional status (614 patients [57.0%] vs 16 patients [15.5%]; P < .001). Of 15 distinct reasons provided by surgeons for opting to proceed with Mohs surgery, the most common were patient desire for treatment with a high cure rate (712 patients [66.0%]), good or excellent patient functional status for age (614 patients [57.0%]), and high risk associated with the tumor based on histology (433 patients [40.2%]).

CONCLUSIONS AND RELEVANCE: This study found that older patients who received Mohs surgery often had high functional status, high-risk tumors, and tumors located on the face. These findings suggest that timely surgical treatment may be appropriate in older patients given that their tumors may be aggressive, painful, disfiguring, and anxiety provoking.

Original languageEnglish (US)
Pages (from-to)770-778
Number of pages9
JournalJAMA Dermatology
Issue number7
StatePublished - Jul 1 2022


  • Aged
  • Carcinoma, Basal Cell/pathology
  • Female
  • Humans
  • Male
  • Mohs Surgery
  • Private Practice
  • Prospective Studies
  • Skin/pathology
  • Skin Neoplasms/pathology

ASJC Scopus subject areas

  • Dermatology


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