Noninvasive ultrasonic measurement of arterial wall motion in mice

Craig J. Hartley, Anilkumar K. Reddy, Sridhar Madala, Mark L. Entman, Lloyd H. Michael, George Taffet

Research output: Contribution to journalConference article

5 Scopus citations

Abstract

To facilitate assessment of arterial function, we developed a noninvasive Doppler method for measuring vessel motion in genetically altered mice. A 20 MHz probe was held by an alligator clip and positioned over the carotid arteries of 16 mice including six 3 to 5-month old wild-type (WT), four 30-month old senescent (Old), two apolipoprotein-E null (ApoE), and four alpha smooth muscle actin null (αSMA) mice. Doppler signals were obtained simultaneously from both vessel walls and from blood flow using one or two probes. The displacement signals from the near and far walls were subtracted to generate a diameter signal from which the excursion and an augmentation index were calculated. The excursion ranged between 13 μm (in ApoE) and 95 μm (in αSMA). The augmentation index was lowest in the WT mice (0.06) and highest in the Old mice (0.29). This noninvasive method is able to identify and confirm characteristic changes in arterial properties associated with age, atherosclerosis, and the absence of vascular tone.

Original languageEnglish (US)
Pages (from-to)3688-3691
Number of pages4
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume26 V
StatePublished - Dec 1 2004
EventConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, United States
Duration: Sep 1 2004Sep 5 2004

Keywords

  • Arterial mechanics
  • Blood velocity
  • Carotid artery
  • Doppler displacement

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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