@inproceedings{c0c69b93d8754052b18a22be25e2418b,
title = "Noninvasive measurement of cerebral venous oxygenation in neonates with a multi-wavelength, fiber-coupled laser diode optoacoustic system",
abstract = "Noninvasive measurement of cerebral venous oxygenation in neonates could provide critical information for clinicians such as cerebral hypoxia without the risks involved with invasive catheterization. Evaluation of cerebral hypoxia is important in many clinical settings such as hypoxic-ischemic encephalopathy, perfusion monitoring in cardiovascular surgery or in traumatic brain injury. By probing the superior sagittal sinus (SSS), a large central cerebral vein, we can obtain stable signals with our recently developed multi-wavelength, fiber-coupled laser diode optoacoustic system for measurement of SSS blood oxygenation. The neonatal SSS oxygenation was measured in the reflection mode through open anterior and posterior fontanelles without obscuration by the overlying calvarium. In the transmission mode it was measured through the skull in the occipital area. Our device is lightweight, easily maneuverable, and user friendly for physicians. We monitored the SSS oxygenation in neonates admitted to the Neonatal Intensive Care Unit (NICU) of UTMB with varying gestation, birth weight and clinical histories to identify normal range and difference between neonates with and without risk factors for cerebral hypoxia.",
keywords = "cerebral ischemia, cerebral oxygenation, imaging, neonatal, noninvasive monitoring, optoacoustic",
author = "Stephen Herrmann and Petrov, {Irene Y.} and Yuriy Petrov and Fonseca, {Rafael A.} and Richardson, {C. Joan} and Ekaterina Shanina and Prough, {Donald S.} and Esenaliev, {Rinat O.}",
note = "Funding Information: This work is supported in part by the National Institutes of Health (Research Grants #R41HD076568 and #R43HD075551 form the Eunice Kennedy Shriver National Institute of Child Health & Human Development, #R41HL10309501 from the National Heart, Lung and Blood Institute, #U54EB007954 from the National Institute of Biomedical Imaging and Bioengineering, and #R41HL10309501 from the National Heart, Lung and Blood Institute), the Texas Emerging Technology Fund, and the Moody Center for Brain and Spinal Cord Injury Research/Mission Connect of UTMB. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIBIB or NIH. Drs. Esenaliev and Prough are co-owners of Noninvasix, Inc., a UTMB-based startup that has licensed the rights to optoacoustic monitoring technology. Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; Photons Plus Ultrasound: Imaging and Sensing 2018 ; Conference date: 28-01-2018 Through 01-02-2018",
year = "2018",
doi = "10.1117/12.2294057",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Wang, {Lihong V.} and Oraevsky, {Alexander A.}",
booktitle = "Photons Plus Ultrasound",
address = "United States",
}