Noninvasive indexes of cardiac systolic and diastolic function in hyperthyroid and senescent mouse

George Taffet, Craig J. Hartley, Xiouying Wen, Thuy Pham, Lloyd H. Michael, Mark L. Entman

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

The mouse is a common model for transgenic manipulation, however, their small size has made hemodynamic study difficult. A noninvasive 10-MHz pulsed Doppler probe was used to measure aortic and mitral flow velocities in anesthetized, intact mice to study the effects of aging and hyperthyroidism (induced by thyroxine) on systolic and diastolic cardiac function. In 10 hyperthyroid mice peak aortic velocity (PAV, an index of systolic function) was 34% higher than in 10 control mice (108 ± 2 vs. 80 ± 3 cm/s, P < 0.05). The ratio of early to late mitral filling velocity (E/A ratio, an index of diastolic function) was 47% higher (5.6 ± 0.8 vs. 3.8 ± 0.2, P < 0.05) in the hyperthyroid mice. In six old (30 mo) mice PAV was similar to eight young (4 mo) mice (73 ± 3 vs. 75 ± 3 cm/s), but the E/A ratio was 59% lower (1.8 ± 0.3 vs. 4.4 ± 0.4, P < 0.05). Despite a wide range of observed heart rates, the systolic and diastolic parameters of the groups were clearly separated. We conclude that cardiac systolic and diastolic function in mice, measured by pulsed Doppler ultrasound, are similar to larger species both in magnitude and in their response to hyperthyroidism and aging.

Original languageEnglish (US)
Pages (from-to)H2204-H2209
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume270
Issue number6 39-6
DOIs
StatePublished - Jun 1996

Keywords

  • Aging
  • Early peak-to-late peak ratio
  • Sarcoplasmic reticulum

ASJC Scopus subject areas

  • Physiology

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