Noninvasive functional imaging of tissue abnormalities using optical coherence tomography

Kirill V. Larin, Joel D. Morrisett, Mohamad G. Ghosn, Valery V. Tuchin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations


Diagnostic imaging techniques are commonly used in a clinical setting for the detection of abnormalities. Optical coherence tomography (OCT) is a relatively novel imaging technique capable of performing structural and functional analysis of various tissue specimens. When structural imaging is limited by the resolution of the system, functional imaging, e.g. through the quantification of the permeability rate of chemical compounds within tissue, can be used to distinguish between normal and abnormal tissue. In this paper we quantitatively demonstrate that the spatiotemporal diffusion characteristics of various compounds in ocular and vascular tissues assessed with OCT-based functional biosensor has superior sensitivity for the detection of early tissue abnormalities when compared to other standard imaging methods. For example, the permeability of glucose molecules in abnormal porcine aorta was found to be more than triple that in normal tissue while structural imaging failed to find the difference. These results suggest that OCT has great capability to enhance and supplement existing biosensing/diagnostic methods in the detection and assessment of tissue abnormalities.

Original languageEnglish (US)
Title of host publicationIEEE Sensors 2010 Conference, SENSORS 2010
Number of pages4
StatePublished - 2010
Event9th IEEE Sensors Conference 2010, SENSORS 2010 - Waikoloa, HI, United States
Duration: Nov 1 2010Nov 4 2010

Publication series

NameProceedings of IEEE Sensors


Other9th IEEE Sensors Conference 2010, SENSORS 2010
Country/TerritoryUnited States
CityWaikoloa, HI

ASJC Scopus subject areas

  • Electrical and Electronic Engineering


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