Noninvasive assessment of vascular mechanics in mice

Craig J. Hartley, Anilkumar K. Reddy, Mark L. Entman, Lloyd H. Michael, George Taffet

Research output: Contribution to journalConference article

Abstract

With the growth of genetic engineering, mice have become common as models of human diseases. Because of the small size and high heart rates in mice, high spatial and temporal resolutions are required for cardiovascular measurements. We have developed and applied high-resolution Doppler probes and signal processing to measure blood velocity in the heart and peripheral vessels of anesthetized mice noninvasively. We can measure velocity pulse arrival times for determining pulse-wave velocity and arterial stiffness; peripheral velocity waveforms as indices of arterial resistance, compliance, and wave reflections; and tail artery velocity for determining systolic and diastolic blood pressure using a tail-cuff. These noninvasive methods are convenient and easy to apply and have been used to detect and evaluate numerous cardiovascular phenotypes in mutant mice.

Original languageEnglish (US)
Pages (from-to)1236-1237
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume2
StatePublished - Dec 1 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002

Keywords

  • Blood flow
  • Cardiovascular
  • Doppler
  • Mice
  • Ultrasound

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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